Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 7/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13697676 | 1.00 | BTK (0.49) | BTKKDM1AMAOBRAB9ACNR1 | |
| SCHEMBL4200640 | 0.83 | CNR2 (0.47) | BTKKDM1AMAOBRAB9ACNR1 | |
| SCHEMBL13929052 | 0.83 | CNR2 (0.47) | BTKKDM1AMAOBRAB9ACNR1 | |
| SCHEMBL4109875 | 0.83 | BTK (0.44) | BTKKDM1AMAOBMERTKJAK1 | |
| SCHEMBL8236915 | 0.83 | BTK (0.44) | BTKKDM1AMAOBMERTKJAK1 | |
| SCHEMBL8236891 | 0.83 | ALDH1A1 (0.44) | BTKRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL8177115 | 0.82 | IRAK4 (0.41) | BTKMERTKJAK1JAK2 | |
| SCHEMBL15289254 | 0.79 | BTK (0.52) | BTKKDM1AMAOBMERTKJAK1 | |
| SCHEMBL4180056 | 0.79 | POLB (0.50) | BTKKDM1AMAOBRAB9ACNR1 | |
| SCHEMBL13929047 | 0.79 | POLB (0.50) | BTKKDM1AMAOBRAB9ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233907-A1 | Pyridopyrimidine Derivatives and Their Use as PDE4 Inhibitors | ASTRAZENECA AB (SE) | 2009-09-17 | — | — | US | disclosed |
| EP-1999130-A1 | PYRIDOPYRIMIDINE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | AstraZeneca AB (SE) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007108750-A1 | PYRIDOPYRIMIDINE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ASTRAZENECA AB (SE) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233907-A1 | Pyridopyrimidine Derivatives and Their Use as PDE4 Inhibitors | PDE4A, PDE4B, PDE12 | BTK 1185/4885KDM1A 1325/4885MAOB 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.