Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 7/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4100776 | 0.92 | KMT2A (0.44) | KMT2AALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL214362 | 0.89 | GAA (0.47) | KMT2AALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL4097621 | 0.87 | MAPT (0.43) | KMT2AALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL214060 | 0.86 | KMT2A (0.42) | KMT2AALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL2735354 | 0.86 | MAPT (0.44) | KMT2AALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL2735426 | 0.85 | ALDH1A1 (0.41) | KMT2AALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL214518 | 0.85 | GAA (0.43) | KMT2AALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL214927 | 0.85 | GAA (0.43) | KMT2AALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL214824 | 0.84 | ALDH1A1 (0.41) | KMT2AALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL215210 | 0.84 | KMT2A (0.42) | KMT2AALDH1A1MAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061768-A2 | IMIDAZOLE-4,5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | Exelixis, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008042282-A2 | IMIDAZOLE-4, 5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | EXELIXIS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |