SCHEMBL4100862

SCHEMBL4100862

Cc1cc(C(=O)CCc2cn(-c3ccc(C(F)(F)F)cc3)nc2C(C)C)ccc1O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESRRG P62508 1/20 0.35
TRPA1 O75762 2/20 0.34
PTGES O14684 1/20 0.34
HSD11B1 P28845 1/20 0.33
GCGR P47871 3/20 0.33
HRH3 Q9Y5N1 2/20 0.32
ALPL P05186 2/20 0.32
TEAD1 P28347 1/20 0.32
TEAD4 Q15561 1/20 0.32
TEAD2 Q15562 1/20 0.32
TEAD3 Q99594 1/20 0.32
HSP90AA1 P07900 1/20 0.32
HSP90AB1 P08238 1/20 0.32
PLAA Q9Y263 1/20 0.32
MMP1 P03956 1/20 0.32
GLP1R P43220 1/20 0.32
GIPR P48546 1/20 0.32
FFAR4 Q5NUL3 1/20 0.32
LDHA P00338 1/20 0.32
LDHB P07195 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4101362 0.85 PPARD (0.46)
SCHEMBL4108779 0.84 PPARD (0.46)
SCHEMBL4098493 0.83 PPARD (0.40)
SCHEMBL4095608 0.82 PPARD (0.38)
SCHEMBL6035573 0.78 DDX3X (0.41) TRPA1
SCHEMBL4105051 0.78 ALPG (0.34) ALPLPLAAALPG
SCHEMBL6034578 0.74 TLR8 (0.44) TRPA1PTGES
SCHEMBL1673291 0.74 PPARD (0.49) HSP90AA1
SCHEMBL5904868 0.73 PPARD (0.55) FFAR4
SCHEMBL3194510 0.73 PPARG (0.44) TRPA1PTGESHSP90AA1HSP90AB1LDHA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090240058-A1 Activator for Peroxisome Proliferator-Activating Receptor Delta NIPPON CHEMIPHAR CO., LTD. (JP) 2009-09-24 US disclosed
EP-1854784-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR ACTIVATING RECEPTOR Nippon Chemiphar Co., Ltd. (JP) 2007-11-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240058-A1 Activator for Peroxisome Proliferator-Activating Receptor Delta PPARG, PPARA, PPARD ESRRG 63/4885TRPA1 1705/4885PTGES 1249/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.