Sugi Predict

Sugi Predict / Targets / DDX3X

DDX3X

ATP-dependent RNA helicase DDX3X · O00571 · DDX3X on Sugi Atlas →

13,982 patent compounds predicted against DDX3X, 10,720 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL8317 SCHEMBL8317 0.47 11/20
SCHEMBL1180082 SCHEMBL1180082 0.50 8/20
SCHEMBL1180247 SCHEMBL1180247 0.42 8/20
SCHEMBL1180249 SCHEMBL1180249 0.42 8/20
SCHEMBL424779 SCHEMBL424779 0.48 6/20
SCHEMBL687547 SCHEMBL687547 0.66 4/20
SCHEMBL333810 SCHEMBL333810 0.46 4/20
SCHEMBL812756 SCHEMBL812756 0.80 3/20
SCHEMBL688197 SCHEMBL688197 0.66 3/20
SCHEMBL546002 SCHEMBL546002 0.63 3/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1143551) 0.59 3/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1187457) 0.56 3/20
SCHEMBL411788 SCHEMBL411788 0.53 3/20
SCHEMBL1313081 SCHEMBL1313081 0.47 3/20
SCHEMBL159539 SCHEMBL159539 0.44 3/20
SCHEMBL1047211 SCHEMBL1047211 1.00 2/20
SCHEMBL711068 SCHEMBL711068 0.89 2/20
SCHEMBL1311061 SCHEMBL1311061 0.79 2/20
SCHEMBL709095 SCHEMBL709095 0.79 2/20
SCHEMBL1248559 SCHEMBL1248559 0.75 2/20

Clinical trials — most relevant to DDX3X by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A Study of KRN23 in Pediatric Patients With X-linked Hypophosphatemic Rickets/Osteomalacia PHASE3COMPLETED
Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft TIssue Sarcoma After Pre-treatment Failure PHASE2COMPLETED
Pharmacogenetics of Disulfiram for Cocaine PHASE2COMPLETED
Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer PHASE1/PHASE2SUSPENDED
Reverse Transcriptase Inhibitors in AGS PHASE2COMPLETED
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma PHASE1/PHASE2COMPLETED
Better Delineation of DDX3X Related Phenotype and Epigenetic Signature. nanUNKNOWN
Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants nanRECRUITING
Studying Chromosomes in Samples From Younger Patients With Neuroblastoma nanCOMPLETED
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve nanUNKNOWN
Exome Analysis in Hearing Impaired Patients nanUNKNOWN
DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study nanRECRUITING
Cause of Familial Testicular Cancer nanCOMPLETED
International PPB/DICER1 Registry nanRECRUITING
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia nanUNKNOWN
Implementing Preemptive Pharmacogenomic Testing for Colorectal Cancer Patients in a Community Oncology Clinic nanCOMPLETED
Personalized Patient Derived Xenograft (pPDX) Modeling to Test Drug Response in Matching Host nanRECRUITING
A Dose-escalation Trial of Stereotactic Ablative Body Radiotherapy for Non-spine Bone & Lymph Node Oligometastates nanCOMPLETED
Prospective Validation of Prostate Biomarkers for Repeat Biopsy nanUNKNOWN
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy nanUNKNOWN
PCD New Gene Discovery nanCOMPLETED
ADAR1 Expression Level in Rectal Cancer nanRECRUITING
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia nanNOT_YET_RECRUITING
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing nanRECRUITING
Gene Analysis in Studying Susceptibility to Wilms Tumor nanCOMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance nanCOMPLETED
RDC Biomarker Study nanRECRUITING
Phenotypes, Biomarkers and Pathophysiology in Spastic Ataxias nanUNKNOWN
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients nanRECRUITING
Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a DDX3X binder may also engage these)

ProteinNameSimilarity
Q62167 — 1.000 Q62167 →
Q5RF43 — 1.000 Q5RF43 →
O15523 — 1.000 O15523 →
Q62095 — 1.000 Q62095 →
Q6GVM6 — 1.000 Q6GVM6 →
P24346 — 1.000 P24346 →
P16381 — 1.000 P16381 →
A5DQS0 — 0.997 A5DQS0 →
O13370 — 0.996 O13370 →
A7TKR8 — 0.996 A7TKR8 →
A3LQ01 — 0.996 A3LQ01 →
A5DZE6 — 0.995 A5DZE6 →
Q75B50 — 0.995 Q75B50 →
Q61496 — 0.995 Q61496 →
A6R3L3 — 0.995 A6R3L3 →
Q4P733 — 0.994 Q4P733 →
Q6FP38 — 0.994 Q6FP38 →
Q3MSQ8 — 0.994 Q3MSQ8 →
P06634 — 0.993 P06634 →
Q8TFK8 — 0.993 Q8TFK8 →
Q84W89 — 0.993 Q84W89 →
Q6CIV2 — 0.993 Q6CIV2 →
P24784 — 0.993 P24784 →
Q6BU54 — 0.993 Q6BU54 →
A6ZWD3 — 0.993 A6ZWD3 →
DDX5 Probable ATP-dependent RNA helicase DDX5 0.992 landscape →
A5A6J2 — 0.992 A5A6J2 →
Q5A4E2 — 0.992 Q5A4E2 →
D0PV95 — 0.992 D0PV95 →
Q8W4R3 — 0.992 Q8W4R3 →