Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.34 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1255227 | 0.85 | PDE2A (0.43) | PDE2ATBXA2RPTGDR | |
| SCHEMBL1255235 | 0.85 | PDE2A (0.50) | ALDH1A1KMT2AMEN1MAPTPDE2A | |
| SCHEMBL12923708 | 0.79 | TBXA2R (0.41) | CYP11B1CYP11B2ALDH1A1KMT2AMEN1 | |
| SCHEMBL4093843 | 0.78 | PTGDR (0.48) | PDE2ATBXA2RPTGDRS1PR1 | |
| SCHEMBL14584258 | 0.76 | CYP11B1 (0.41) | CYP11B1CYP11B2ALDH1A1KMT2AMEN1 | |
| SCHEMBL14562372 | 0.75 | HTR2A (0.36) | ALDH1A1MAPTTBXA2RPTGDR | |
| SCHEMBL11918206 | 0.75 | PDE2A (0.44) | PDE2ATBXA2RPTGDR | |
| SCHEMBL4105569 | 0.74 | KMT2A (0.52) | KMT2AMEN1KDM4EL3MBTL1MAPT | |
| SCHEMBL12923704 | 0.74 | SIRT1 (0.53) | ALDH1A1KMT2AMEN1KDM4EL3MBTL1 | |
| SCHEMBL9658727 | 0.74 | SIRT1 (0.56) | KMT2AMEN1KDM4EL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120115921-A1 | FLUORO SUBSTITUTED CYCLOALKANOINDOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2012-05-10 | — | — | US | disclosed |
| US-20120115921-A1 | FLUORO SUBSTITUTED CYCLOALKANOINDOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2012-05-10 | — | — | US | disclosed |
| US-20100081696-A1 | FLUORO SUBSTITUTED CYCLOALKANOINDOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | BERTHELETTE CARL | 2010-04-01 | — | — | US | disclosed |
| US-7618994-B2 | Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment | MERCK FROSST CANADA LTD. (CA) | 2009-11-17 | — | — | US | disclosed |
| US-7618994-B2 | Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment | MERCK FROSST CANADA LTD. (CA) | 2009-11-17 | — | — | US | disclosed |
| US-20080033028-A1 | Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment | BERTHELETTE CARL | 2008-02-07 | — | — | US | disclosed |
| US-20080033028-A1 | Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment | BERTHELETTE CARL | 2008-02-07 | — | — | US | disclosed |
| US-7317036-B2 | Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment | MERCK FROSST CANADA & CO. (CA) | 2008-01-08 | — | — | US | disclosed |
| US-7317036-B2 | Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment | MERCK FROSST CANADA & CO. (CA) | 2008-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115921-A1 | FLUORO SUBSTITUTED CYCLOALKANOINDOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | PTGER1, PTGER3, PTGER2 | CYP11B1 69/4885CYP11B2 40/4885ALDH1A1 1728/4885 |
| US-20080033028-A1 | Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment | PTGER1, PTGER3, PTGER2 | CYP11B1 69/4885CYP11B2 40/4885ALDH1A1 1728/4885 |
| US-20100081696-A1 | FLUORO SUBSTITUTED CYCLOALKANOINDOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | PTGER1, PTGER3, PTGER2 | CYP11B1 69/4885CYP11B2 40/4885ALDH1A1 1728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.