Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048480 | 0.94 | MEN1 (0.39) | NOTUMHSP90AA1HSP90AB1TP53HSD17B13 | |
| SCHEMBL2900829 | 0.85 | NOTUM (0.68) | NOTUMCHEK1AURKADAPK3JAK2 | |
| SCHEMBL1222427 | 0.81 | NOTUM (0.54) | NOTUMHSP90AA1HSP90AB1PPARACYP1A2 | |
| SCHEMBL8231067 | 0.81 | PTPN1 (0.40) | NOTUMMAP4K4HSP90AA1HSP90AB1HSD17B13 | |
| SCHEMBL1544031 | 0.81 | TP53 (0.47) | TP53THRBCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL2535956 | 0.80 | MEN1 (0.47) | NOTUMHSP90AA1HSP90AB1TP53CYP1A2 | |
| SCHEMBL4049004 | 0.78 | TP53 (0.43) | FLT1KDRCLK4HSP90AA1HSP90AB1 | |
| SCHEMBL30948143 | 0.76 | SCD (0.41) | NOTUMHSP90AA1HSP90AB1TP53LMNA | |
| SCHEMBL5733016 | 0.75 | ALDH1A1 (0.49) | TP53THRBCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4101696 | 0.74 | GRM5 (0.38) | NOTUMTP53HSD17B13LMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111821-A1 | AMINO 1,2,4-TRIAZOLE DERIVATIVES AS MODULATORS OF MGLUR5 | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111821-A1 | AMINO 1,2,4-TRIAZOLE DERIVATIVES AS MODULATORS OF MGLUR5 | GRM5, GRIK5, GRM1 | NOTUM 2822/4885CHEK1 4588/4885AURKA 2917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.