Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 7/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22072959 | 0.94 | PLAU (0.40) | PLAUALDH1A1L3MBTL1POLBPDPK1 | |
| SCHEMBL9091872 | 0.91 | CYP1A2 (0.43) | NCF1ALDH1A1L3MBTL1POLBNPC1 | |
| SCHEMBL15364623 | 0.83 | AR (0.45) | NCF1ALDH1A1ARKDM4EUSP2 | |
| SCHEMBL15365210 | 0.83 | AR (0.45) | NCF1ALDH1A1ARKDM4EUSP2 | |
| SCHEMBL15365341 | 0.83 | AR (0.45) | NCF1ALDH1A1ARKDM4EUSP2 | |
| SCHEMBL6739587 | 0.83 | KDM1A (0.43) | ALDH1A1L3MBTL1POLBPDPK1 | |
| SCHEMBL9685009 | 0.82 | EGFR (0.34) | NCF1PLAUALDH1A1L3MBTL1POLB | |
| SCHEMBL17525544 | 0.81 | MAPT (0.50) | ALDH1A1L3MBTL1POLBMEN1KMT2A | |
| SCHEMBL25427456 | 0.80 | L3MBTL1 (0.44) | PLAUALDH1A1L3MBTL1POLBMEN1 | |
| SCHEMBL23915572 | 0.80 | L3MBTL1 (0.53) | PLAUALDH1A1L3MBTL1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105633-A1 | ULTRASOUND ASSEMBLY FOR USE WITH LIGHT ACTIVATED DRUGS | TACHIBANA KATSURO | 2009-04-23 | — | — | US | disclosed |
| US-20040229830-A1 | Delivery of therapeutic compositions using ultrasound | TACHIBANA KATSURO (JP) | 2004-11-18 | — | — | US | disclosed |
| US-20040059313-A1 | Ultrasound assembly for use with light activated drugs | EKOS L.L.C. | 2004-03-25 | — | — | US | disclosed |
| US-20030157024-A1 | ULTRASOUND ASSEMBLY FOR USE WITH LIGHT ACTIVATED DRUGS | TACHIBANA KATSURO (JP) | 2003-08-21 | — | — | US | disclosed |
| US-20030092667-A1 | Delivery of therapeutic compositions using ultrasound | EKOS L.L.C. | 2003-05-15 | — | — | US | disclosed |
| EP-0724457-B1 | RADIATION SENSITIZATION USING TEXAPHYRINS | UNIV TEXAS (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6527759-B1 | Ultrasound assembly for use with light activated drugs | EKOS CORPORATION | 2003-03-04 | — | — | US | disclosed |
| US-6176842-B1 | Ultrasound assembly for use with light activated drugs | EKOS CORPORATION | 2001-01-23 | — | — | US | disclosed |
| US-6072038-A | HYDROXYLATED TEXAPHYRIN-BIOMOLECULE CONJUGATE; FOR RADIATION SENSITIZATION IN X-RAY THERAPY FOR ANTITUMOR AND ANTIATHEROMA THERAPY | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2000-06-06 | — | — | US | disclosed |
| US-6069140-A | RADIATION SENSITIZERS | THE BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM (US) | 2000-05-30 | — | — | US | disclosed |
| WO-1999013943-A1 | ULTRASOUND ASSEMBLY FOR USE WITH LIGHT ACTIVATED DRUGS | EKOS CORPORATION (US) | 1999-03-25 | — | — | WO | disclosed |
| US-5801229-A | RADIATION SENSITIZERS; ANTITUMOR AGENTS | THE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) | 1998-09-01 | — | — | US | disclosed |
| US-5632970-A | Fluoresence detection using texaphyrins | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS (US) | 1997-05-27 | — | — | US | disclosed |
| US-5622946-A | TREATMENT OF NEOPLASM OR ATHEROMA | PHARMACYCLICS, INC. (US) | 1997-04-22 | — | — | US | disclosed |
| US-5587371-A | EFFECTIVE FOR TREATING HYPOXIC AREAS OF SOLID NEOPLASMS | PHARMACYCLICS, INC. (US) | 1996-12-24 | — | — | US | disclosed |
| US-5583220-A | Pyrole nitrogen-substituted texaphyrins | PHARMACYCLICS, INC. (US) | 1996-12-10 | — | — | US | disclosed |
| US-5580543-A | TEXAPHYRINS AS RADIATION SENSITIZERS | PHARMACYCLICS, INC. (US) | 1996-12-03 | — | — | US | disclosed |
| US-5567687-A | USEFUL IN PHOTODYNAMIC THERAPY AND LIGHT-INDUCED CLEAVAGE OF A POLYMER OF DEOXYRIBONUCLEIC ACID | UNIVERSITY OF TEXAS (US) | 1996-10-22 | — | — | US | disclosed |
| EP-0724457-A1 | RADIATION SENSITIZATION USING TEXAPHYRINS | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995010307-A1 | RADIATION SENSITIZATION USING TEXAPHYRINS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1995-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030092667-A1 | Delivery of therapeutic compositions using ultrasound | SON, XRCC6, DNASE1 | NCF1 1405/4885PLAU 33/4885ALDH1A1 4703/4885 |
| US-20040229830-A1 | Delivery of therapeutic compositions using ultrasound | SON, XRCC6, DNASE1 | NCF1 1405/4885PLAU 33/4885ALDH1A1 4703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.