Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29124557 | 0.89 | HRH3 (0.50) | HRH3KDM4EGAAMAPTALDH1A1 | |
| SCHEMBL572453 | 0.81 | ALK (0.48) | SMN1; SMN2CYP2C19 | |
| SCHEMBL15192190 | 0.81 | ALK (0.48) | SMN1; SMN2CYP2C19 | |
| SCHEMBL14311677 | 0.80 | ALDH1A1 (0.53) | HRH3KDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL2033579 | 0.76 | MAPK1 (0.60) | KDM4EMAPTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL20985378 | 0.75 | HRH3 (0.46) | HRH3ALDH1A1CYP2D6 | |
| SCHEMBL20985376 | 0.75 | HRH3 (0.46) | HRH3ALDH1A1CYP2D6 | |
| SCHEMBL10240068 | 0.75 | ALDH1A1 (0.63) | HRH3KDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL6734904 | 0.74 | DDB1 (0.59) | HRH3ALDH1A1SMN1; SMN2PRMT6TDP1 | |
| SCHEMBL20837294 | 0.74 | MAPT (0.62) | KDM4EGAAMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061786-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE | Biogen Idec MA Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008030584-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF INTERLEUKIN- 1 RECEPTOR-ASSOCIATED KINASE | BIOGEN IDEC MA INC. (US) | 2008-03-13 | — | — | WO | disclosed |