⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27540820 | 0.81 | — | — | |
| SCHEMBL29912802 | 0.80 | — | — | |
| SCHEMBL165172 | 0.80 | — | — | |
| SCHEMBL29457483 | 0.78 | — | — | |
| SCHEMBL274632 | 0.78 | — | — | |
| SCHEMBL25278959 | 0.77 | — | — | |
| SCHEMBL12806923 | 0.77 | — | — | |
| SCHEMBL135723 | 0.77 | — | — | |
| SCHEMBL29892904 | 0.77 | — | — | |
| SCHEMBL116061 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2499 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115557905-B | Novel green method for preparing aminopyrazine and application of aminopyrazine in synthesis of medical intermediate | 湖北瑞凯兴科技股份有限公司 | 2025-01-03 | — | — | CN | claimed |
| US-12134613-B2 | Method for the manufacture of 3-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine and polymorphic forms thereof | ASTRAZENECA AB (SE) | 2024-11-05 | — | — | US | claimed |
| CN-117924295-A | Furimazine derivative and preparation method and application thereof | 广州博鹭腾生物科技有限公司 | 2024-04-26 | — | — | CN | claimed |
| CN-117903145-A | Synthesis method of 5-bromo-1H-pyrazolo [3,4-b ] pyrazine | 白银康寓信生物科技有限公司 | 2024-04-19 | — | — | CN | claimed |
| CN-117820242-A | Preparation method of 3, 5-dibromo-1-methylpyrazine-2 (1H) -ketone | 湖北广济药业股份有限公司 | 2024-04-05 | — | — | CN | claimed |
| WO-2023279938-A1 | 2,6,8-POLYSUBSTITUTED IMIDAZO[1,2-A]PYRAZINE, AND SYNTHESIS METHOD THEREFOR AND USE THEREOF | 无锡市第二人民医院 | 2023-01-12 | — | — | WO | claimed |
| CN-115557905-A | Green new method for preparing aminopyrazine and application of aminopyrazine in synthesis of medical intermediate | 武汉科技大学 | 2023-01-03 | — | — | CN | claimed |
| US-20220048904-A1 | Improved Method for the Manufacture of 3-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine and polymorphic forms thereof | ASTRAZENECA AB (SE) | 2022-02-17 | — | — | US | claimed |
| CN-215811715-U | Intermediate 3, 5-dibromo-2-aminopyrazine recrystallization sampling device | 安徽敬同药业有限公司 | 2022-02-11 | — | — | CN | claimed |
| CN-113480543-A | 2,6, 8-polysubstituted imidazo [1,2-a ] pyrazine and synthetic method and application thereof | 无锡市第二人民医院 | 2021-10-08 | — | — | CN | claimed |
| CN-105622526-A | Preparation method of 2-aminopyrazine derivatives | UNIV HUBEI TECHNOLOGY | 2016-06-01 | — | — | CN | claimed |
| CN-105327609-A | Treating agent for removing three kinds of dioxin-like compounds in waste incineration waste off gas | CHEN YIJUN | 2016-02-17 | — | — | CN | claimed |
| CN-105327598-A | Treating method for removing three kinds of dioxin-like compounds in waste incineration waste off gas | CHEN YIJUN | 2016-02-17 | — | — | CN | claimed |
| CN-104016990-A | Imidazopyrazine derivatives as well as preparation method and application thereof | UNIV SHANDONG | 2014-09-03 | — | — | CN | claimed |
| US-20110098310-A1 | NOVEL COMPOUNDS, USE AND PREPARATION THEREOF | BIOVITRUM AB (SE) | 2011-04-28 | — | — | US | claimed |
| US-7923185-B2 | Pyrazine containing charge transport layer photoconductors | XEROX CORPORATION (US) | 2011-04-12 | — | — | US | claimed |
| JP-2011510948-A | — | — | 2011-04-07 | — | — | JP | claimed |
| EP-2252597-A2 | NOVEL COMPOUNDS, USE AND PREPARATION THEREOF | Akinion Pharmaceuticals AB (SE) | 2010-11-24 | — | — | EP | claimed |
| US-20090274968-A1 | PYRAZINE CONTAINING CHARGE TRANSPORT LAYER PHOTOCONDUCTORS | XEROX CORPORATION (US) | 2009-11-05 | — | — | US | claimed |
| WO-2009095399-A2 | PYRAZINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHBITORS | AKINION PHARMACEUTICALS AB (SE) | 2009-08-06 | — | — | WO | claimed |