Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 8/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 3/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214517 | 0.93 | RAB9A (0.37) | RAB9AKDM4EMAPTLMNANPC1 | |
| SCHEMBL215845 | 0.85 | IRAK4 (0.39) | RAB9AKDM4EMAPTLMNANPC1 | |
| SCHEMBL214926 | 0.83 | RAB9A (0.37) | RAB9AKDM4EMAPTLMNANPC1 | |
| SCHEMBL214637 | 0.82 | MAOB (0.49) | RAB9AKDM4EMAPTLMNANPC1 | |
| SCHEMBL215374 | 0.80 | ABL1 (0.37) | RAB9AKDM4EMAPTLMNANPC1 | |
| SCHEMBL214506 | 0.79 | MAPK14 (0.34) | RAB9AKDM4EMAPTLMNANPC1 | |
| SCHEMBL214751 | 0.79 | BTK (0.38) | RAB9AKDM4EMAPTLMNANPC1 | |
| SCHEMBL214920 | 0.79 | MAPK14 (0.42) | MAPK14 | |
| Hydrochloric Acid SCHEMBL215304 | 0.78 | MAPK14 (0.34) | RAB9AKDM4EMAPTLMNANPC1 | |
| SCHEMBL213660 | 0.77 | TOP2A (0.35) | RAB9AKDM4EMAPTLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061768-A2 | IMIDAZOLE-4,5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | Exelixis, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008042282-A2 | IMIDAZOLE-4, 5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | EXELIXIS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |