Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.39 |
| ▸ | NQO2 | P16083 | 7/20 | 0.39 |
| ▸ | KDM1A | O60341 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4109503 | 0.96 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DMTNR1A | |
| SCHEMBL4115966 | 0.86 | KDM1A (0.39) | PDE4APDE4BPDE4CPDE4DMTNR1A | |
| SCHEMBL4110521 | 0.86 | KDM1A (0.39) | PDE4APDE4BPDE4CPDE4DMTNR1A | |
| SCHEMBL2245728 | 0.85 | KDM1A (0.40) | PDE4APDE4BPDE4CPDE4DMTNR1A | |
| SCHEMBL4109930 | 0.85 | KDM1A (0.39) | PDE4APDE4BPDE4CPDE4DMTNR1A | |
| SCHEMBL1616408 | 0.84 | ACP1 (0.40) | PDE4APDE4BPDE4CPDE4DKDM1A | |
| SCHEMBL1615479 | 0.81 | PDE4B (0.42) | PDE4APDE4BPDE4CPDE4DKDM1A | |
| SCHEMBL1615738 | 0.81 | ACP1 (0.39) | KDM1AMAOAMAOB | |
| SCHEMBL1615578 | 0.79 | CYP1A2 (0.45) | KDM1AMAOAMAOBTRPV1 | |
| SCHEMBL1613862 | 0.79 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227584-A1 | 2-AMINOQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-10 | — | — | US | claimed |
| US-20090227584-A1 | 2-AMINOQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227584-A1 | 2-AMINOQUINOLINE DERIVATIVES | HTR5A, HTR2C, HTR2B | PDE4A 352/4885PDE4B 228/4885PDE4C 381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.