Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | GALR3 | O60755 | 1/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.33 |
| ▸ | ULK1 | O75385 | 1/20 | 0.33 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4099757 | 0.84 | MAPT (0.46) | OPRK1TP53LMNAALDH1A1MAPT | |
| SCHEMBL708078 | 0.77 | OPRK1 (0.64) | OPRK1SMN1; SMN2POLBALDH1A1MAPT | |
| SCHEMBL708077 | 0.77 | OPRK1 (0.64) | OPRK1SMN1; SMN2POLBALDH1A1MAPT | |
| SCHEMBL4103444 | 0.77 | RHOA (0.41) | OPRK1POLBALDH1A1MAPTMAPK1 | |
| SCHEMBL5316300 | 0.77 | RHOA (0.41) | OPRK1POLBALDH1A1MAPTMAPK1 | |
| SCHEMBL10281620 | 0.74 | OPRK1 (0.62) | OPRK1SMN1; SMN2POLBALDH1A1MAPT | |
| SCHEMBL708572 | 0.74 | OPRK1 (0.52) | OPRK1SMN1; SMN2ALDH1A1MAPTULK1 | |
| SCHEMBL708573 | 0.74 | OPRK1 (0.52) | OPRK1SMN1; SMN2ALDH1A1MAPTULK1 | |
| SCHEMBL6125265 | 0.74 | OPRK1 (0.62) | OPRK1SMN1; SMN2POLBALDH1A1MAPT | |
| SCHEMBL1288565 | 0.72 | SMN1; SMN2 (0.42) | OPRK1SMN1; SMN2MAPTPDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227555-A2 | Novel Pyridine Compounds | ASTRAZENECA AB (SE) | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227555-A2 | Novel Pyridine Compounds | P2RY12, P2RY1, P2RY11 | OPRK1 1185/4885TP53 4775/4885SMN1; SMN2 4121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.