Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.49 |
| ▸ | USP2 | O75604 | 5/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3272974 | 0.85 | CYP1A2 (0.48) | KDM4ECYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL3267065 | 0.85 | MEN1 (0.53) | KDM4EHTTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4123545 | 0.82 | CYP1A2 (0.47) | KDM4ECYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL3268616 | 0.80 | PDGFRB (0.53) | KDM4EHTTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3267015 | 0.79 | MEN1 (0.47) | KDM4EHTTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3266721 | 0.78 | CYP1A2 (0.47) | CYP1A2CYP3A4CYP2C19CYP2D6USP2 | |
| SCHEMBL3266911 | 0.78 | AURKA (0.54) | KDM4EHTTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3268223 | 0.77 | QRFPR (0.50) | KDM4EHTTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3266890 | 0.77 | AURKA (0.48) | CYP1A2CYP3A4CYP2C19CYP2D6USP2 | |
| SCHEMBL3266795 | 0.77 | CYP2D6 (0.47) | KDM4EHTTCYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8350028-B2 | 2-aminoquinolines | HOFMANN-LA ROCHE INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-20090233927-A1 | 2-AMINOQUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233927-A1 | 2-AMINOQUINOLINES | HTR5A, HTR2C, HTR2B | KDM4E 1211/4885HTT 431/4885POLB 2861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.