Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metoprolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 4/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | NPY1R | P25929 | 1/20 | 1.00 |
| ▸ | NPY2R | P49146 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.84 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.84 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.84 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.84 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.84 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.84 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | CNR1 | P21554 | 1/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metoprolol SCHEMBL19211129 | 1.00 | TDP1 (1.00) | TDP1PMP22NPY1RNPY2RNPSR1 | |
| Metoprolol SCHEMBL29995613 | 1.00 | TDP1 (1.00) | TDP1PMP22NPY1RNPY2RNPSR1 | |
| Metoprolol SCHEMBL1649321 | 1.00 | TDP1 (1.00) | TDP1PMP22NPY1RNPY2RNPSR1 | |
| Metoprolol SCHEMBL29367290 | 1.00 | TDP1 (1.00) | TDP1PMP22NPY1RNPY2RNPSR1 | |
| Metoprolol SCHEMBL4881939 | 1.00 | TDP1 (1.00) | TDP1PMP22NPY1RNPY2RNPSR1 | |
| (S)-Metoprolol SCHEMBL141366 | 1.00 | TDP1 (1.00) | TDP1PMP22NPY1RNPY2RNPSR1 | |
| Metoprolol SCHEMBL2124595 | 0.99 | TDP1 (0.98) | TDP1PMP22NPY1RNPY2RNPSR1 | |
| Metoprolol SCHEMBL4879331 | 0.98 | TDP1 (0.96) | TDP1PMP22NPY1RNPY2RNPSR1 | |
| Metoprolol SCHEMBL28264735 | 0.97 | TDP1 (0.94) | TDP1PMP22NPY1RNPY2RNPSR1 | |
| (S)-Metoprolol SCHEMBL3123844 | 0.93 | ADRB2 (0.88) | TDP1PMP22NPY1RNPY2RNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 9615 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4691556-A2 | HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF | H. Lundbeck A/S (DK) | 2026-02-11 | — | — | EP | claimed |
| US-20250382291-A1 | SUBSTITUTED PYRROLO[2,3-b]PYRIDINES FOR SUPPRESSING TOXIC ENDOPLASMIC RETICULUM STRESS | UNIV COLUMBIA (US) | 2025-12-18 | — | — | US | claimed |
| US-20250302887-A1 | AMMONIA OXIDIZING MICROORGANISMS FOR THE REGULATION OF BLOOD PRESSURE | AOBIOME LLC (US) | 2025-10-02 | — | — | US | claimed |
| EP-4615449-A1 | METHOD TO PREVENT AND TREAT DIABETIC RETINOPATHY BY CALCIUM CHANNEL BLOCKERS, ANGIOTENSIN CONVERTING ENZYME INHIBITORS, AND ANGIOTENSIN RECEPTOR BLOCKERS | Weinberg, Assa (US) | 2025-09-17 | — | — | EP | claimed |
| US-20250262195-A1 | METHOD TO PREVENT AND TREAT DIABETIC RETINOPATHY BY CALCIUM CHANNEL BLOCKERS, ANGIOTENSIN CONVERTING ENZYME INHIBITORS, AND ANGIOTENSIN RECEPTOR BLOCKERS | WEINBERG ASSA (US) | 2025-08-21 | — | — | US | claimed |
| US-20250264469-A1 | METHODS FOR IMPROVING OUTCOMES FOR HEMATOPOIETIC CELL TRANSPLANT RECIPIENTS AT RISK FOR BRONCHIOLITIS OBLITERANS SYNDROME | CHILDREN'S HOSPITAL MEDICAL CENTER | 2025-08-21 | — | — | US | claimed |
| EP-4598526-A1 | METHOD TO PREVENT AND TREAT GLAUCOMA BY CALCIUM CHANNEL BLOCKERS, ANGIOTENSIN CONVERTING ENZYME INHIBITORS, AND ANGIOTENSIN RECEPTOR BLOCKERS | Weinberg, Assa (US) | 2025-08-13 | — | — | EP | claimed |
| US-20250228831-A1 | METHOD TO PREVENT AND TREAT GLAUCOMA BY CALCIUM CHANNEL BLOCKERS, ANGIOTENSIN CONVERTING ENZYME INHIBITORS, AND ANGIOTENSIN RECEPTOR BLOCKERS | WEINBERG ASSA (US) | 2025-07-17 | — | — | US | claimed |
| US-20250223370-A1 | METHODS OF TREATING DISORDERS USING ANTI-NATRIURETIC PEPTIDE RECEPTOR 1 (NPR1) ANTIBODIES | NOVARTIS AG (CH) | 2025-07-10 | — | — | US | claimed |
| WO-2025131019-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF INHIBIN SUBUNIT BETA E (INHBE) | SHANGHAI ARGO BIOPHARMACEUTICAL CO., LTD. (CN) | 2025-06-26 | — | — | WO | claimed |
| US-5260066-A | Cryogel bandage containing therapeutic agent | SRCHEM INCORPORATED (US) | 1993-11-09 | — | — | US | claimed |
| WO-1993015725-A1 | COMPOSITIONS AND PROCESSES FOR THE SUSTAINED RELEASE OF DRUGS | PITMAN-MOORE, INC. (US) | 1993-08-19 | — | — | WO | claimed |
| EP-0487237-A1 | New optically active metoprolol tartrate salts, and method of preparing them, and method of preparing optically active metoprolol from the tartrate salts | Nitto Denko Co. Ltd. (JP) | 1992-05-27 | — | — | EP | claimed |
| US-4952402-A | EDIBLE TASTE-MASKED DRUGS; MICROMATRIX ACTIVE MATERIAL COATED WITH NONTOXIC POLYMER; LIQUIDS; TABLETS | ELAN CORPORATION, P.L.C. (IE) | 1990-08-28 | — | — | US | claimed |
| EP-0148811-B1 | PHARMACEUTICAL COMPOSITION | LEJUS MEDICAL AKTIEBOLAG (SE) | 1989-09-06 | — | — | EP | claimed |
| US-4780318-A | DIFFERENT SOLUBILITIES AT DIFFERENT PHS | LEJUS MEDICAL AKTIEBOLAG (SE) | 1988-10-25 | — | — | US | claimed |
| EP-0189861-A2 | Percutaneous absorption accelerator for ionic water-soluble medicine | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1986-08-06 | — | — | EP | claimed |
| EP-0079522-B1 | N-CARBOXYMETHYL(AMIDINO)LYSYL-PROLINE ANTIHYPERTENSIVE AGENTS | MERCK & CO. INC. (US) | 1986-05-07 | — | — | EP | claimed |
| EP-0148811-A1 | Pharmaceutical composition | LEJUS MEDICAL AKTIEBOLAG (SE) | 1985-07-17 | — | — | EP | claimed |
| US-4281654-A | Drug delivery system for controlled ocular therapy | ALZA CORPORATION (US) | 1981-08-04 | — | — | US | claimed |