Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 13/20 | 0.52 |
| ▸ | INSR | P06213 | 12/20 | 0.52 |
| ▸ | IGF1R | P08069 | 11/20 | 0.52 |
| ▸ | FLT3 | P36888 | 3/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | PRKCG | P05129 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1892349 | 0.88 | INSR (0.48) | ALKINSRIGF1RFLT3AURKA | |
| SCHEMBL1896333 | 0.87 | INSR (0.47) | ALKINSRIGF1RFLT3AURKA | |
| SCHEMBL1889863 | 0.87 | ALK (0.57) | ALKINSRIGF1RFLT3AURKA | |
| SCHEMBL1885492 | 0.83 | INSR (0.49) | ALKINSRIGF1RFLT3AURKA | |
| SCHEMBL1898672 | 0.81 | INSR (0.47) | ALKINSRIGF1RFLT3AURKA | |
| SCHEMBL1885506 | 0.78 | IGF1R (0.62) | ALKINSRIGF1RFLT3AURKA | |
| SCHEMBL1434540 | 0.77 | IGF1R (0.71) | ALKINSRIGF1RFLT3AURKA | |
| SCHEMBL1893142 | 0.77 | IGF1R (0.60) | ALKINSRIGF1RFLT3AURKA | |
| SCHEMBL1897853 | 0.76 | IGF1R (0.59) | ALKINSRIGF1RFLT3AURKA | |
| SCHEMBL4548411 | 0.76 | IGF1R (0.59) | ALKINSRIGF1RFLT3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023745-A1 | Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023745-A1 | Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors | MAP3K3, MAP3K1, MAP3K19 | ALK 517/4885INSR 922/4885IGF1R 760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.