Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 7/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.33 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.33 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4118325 | 0.91 | KCNA5 (0.42) | KCNA5KCNH2NPC1THRBMMP1 | |
| SCHEMBL4105235 | 0.89 | KCNA5 (0.39) | KCNA5KCNH2NPC1THRBMMP1 | |
| SCHEMBL3917734 | 0.88 | KCNA5 (0.41) | KCNA5KCNH2NPC1THRBMMP1 | |
| SCHEMBL3915793 | 0.84 | KCNA5 (0.46) | KCNA5KCNH2THRBMMP1MMP9 | |
| SCHEMBL3914495 | 0.84 | KCNA5 (0.50) | KCNA5KCNH2THRBMMP1MMP9 | |
| SCHEMBL3917221 | 0.81 | KCNA5 (0.45) | KCNA5KCNH2MMP1MMP9MMP13 | |
| SCHEMBL4131059 | 0.81 | NPC1 (0.44) | KCNA5NPC1MMP1MMP9MMP13 | |
| SCHEMBL3914441 | 0.80 | KCNA5 (0.50) | KCNA5KCNH2THRBMMP1MMP9 | |
| SCHEMBL3915828 | 0.80 | KCNA5 (0.48) | KCNA5KCNH2THRBMMP1MMP9 | |
| SCHEMBL3916079 | 0.80 | KCNA5 (0.48) | KCNA5KCNH2THRBMMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035392-A1 | IMIDAZOLE KV1. 5 POTASSIUM CHANNEL INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007149874-A1 | IMIDAZOLIDINONE KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | WO | disclosed |