Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3917734 | 0.85 | KCNA5 (0.41) | NPC1MEN1KMT2AEPHX2RAB9A | |
| SCHEMBL4102234 | 0.83 | NPC1 (0.42) | NPC1MEN1KMT2AEPHX2RAB9A | |
| SCHEMBL4105235 | 0.82 | KCNA5 (0.39) | NPC1MEN1KMT2AEPHX2RAB9A | |
| SCHEMBL4108759 | 0.82 | NPC1 (0.44) | NPC1MEN1KMT2AEPHX2RAB9A | |
| SCHEMBL4118325 | 0.82 | KCNA5 (0.42) | NPC1MEN1KMT2AEPHX2RAB9A | |
| SCHEMBL4113537 | 0.81 | KCNA5 (0.38) | NPC1MEN1KMT2AEPHX2RAB9A | |
| SCHEMBL3915740 | 0.80 | KCNA5 (0.44) | NPC1MEN1KMT2AEPHX2RAB9A | |
| SCHEMBL4505375 | 0.80 | NPC1 (0.42) | NPC1MEN1KMT2AEPHX2RAB9A | |
| SCHEMBL3915202 | 0.77 | KCNA5 (0.54) | NPC1MEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL3917221 | 0.77 | KCNA5 (0.45) | KCNA5MMP1MMP9MMP13GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035392-A1 | IMIDAZOLE KV1. 5 POTASSIUM CHANNEL INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007149874-A1 | IMIDAZOLIDINONE KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | WO | disclosed |