Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | IL18 | Q14116 | 1/20 | 0.42 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.41 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4114725 | 1.00 | HTT (0.47) | HTTSMN1; SMN2IDO1HDAC1HDAC7 | |
| SCHEMBL4120752 | 1.00 | HTT (0.47) | HTTSMN1; SMN2IDO1HDAC1HDAC7 | |
| SCHEMBL4120754 | 1.00 | HTT (0.47) | HTTSMN1; SMN2IDO1HDAC1HDAC7 | |
| SCHEMBL4102761 | 0.94 | HTT (0.52) | HTTSMN1; SMN2IDO1HDAC1HDAC7 | |
| SCHEMBL4102762 | 0.94 | HTT (0.52) | HTTSMN1; SMN2IDO1HDAC1HDAC7 | |
| SCHEMBL4112937 | 0.89 | KMT2A (0.49) | HTTSMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL4112935 | 0.89 | KMT2A (0.49) | HTTSMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL4109095 | 0.88 | HTT (0.47) | HTTSMN1; SMN2HDAC1HDAC7HDAC8 | |
| SCHEMBL4104738 | 0.88 | SMN1; SMN2 (0.47) | HTTSMN1; SMN2HDAC1HDAC7HDAC8 | |
| SCHEMBL4114980 | 0.88 | HTT (0.56) | HTTSMN1; SMN2HDAC1HDAC7HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546452-B2 | S1P3 receptor antagonist | TOA EIYO LTD. (JP) | 2013-10-01 | — | — | US | disclosed |
| US-20090170895-A1 | S1P3 RECEPTOR ANTAGONIST | TOA EIYO LTD. (JP) | 2009-07-02 | — | — | US | disclosed |
| EP-1935874-A1 | S1P3 RECEPTOR ANTAGONIST | TOA EIYO LTD. (JP) | 2008-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170895-A1 | S1P3 RECEPTOR ANTAGONIST | S1PR3, S1PR5, GPR3 | HTT 4148/4885SMN1; SMN2 2497/4885IDO1 2695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.