Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27385701 | 1.00 | NPSR1 (0.47) | NPSR1HCAR2GLO1ALDH1A1CYP2D6 | |
| SCHEMBL4115120 | 1.00 | NPSR1 (0.47) | NPSR1HCAR2GLO1ALDH1A1CYP2D6 | |
| Potassium Ion SCHEMBL29000372 | 0.83 | NPSR1 (0.44) | NPSR1HCAR2GLO1ALDH1A1CYP2D6 | |
| SCHEMBL4109419 | 0.83 | NPSR1 (0.63) | NPSR1HCAR2GLO1ALDH1A1CYP2D6 | |
| SCHEMBL4247912 | 0.83 | NPSR1 (0.63) | NPSR1HCAR2GLO1ALDH1A1CYP2D6 | |
| SCHEMBL4109423 | 0.83 | NPSR1 (0.63) | NPSR1HCAR2GLO1ALDH1A1CYP2D6 | |
| SCHEMBL7895381 | 0.80 | HCAR2 (0.50) | NPSR1HCAR2ALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL265673 | 0.79 | — | — | |
| SCHEMBL8382034 | 0.79 | — | — | |
| SCHEMBL11149236 | 0.79 | NPSR1 (0.48) | NPSR1HCAR2GLO1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100516061-C | Pyridine derivatives as NMDA receptor ligands | HOFFMANN LA ROCHE (CH) | 2009-07-22 | — | — | CN | disclosed |
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| EP-1939205-A1 | TRICYCLIC COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007022015-A1 | METHODS TO EVALUATE AMYLOID BETA-LOWERING AGENTS USING WILD-TYPE MICE | GEORGETOWN UNIVERSITY (US) | 2007-02-22 | — | — | WO | disclosed |
| CN-1585762-A | Pyridine derivatives as NMDA receptor ligands | HOFFMANN LA ROCHE (CH) | 2005-02-23 | — | — | CN | disclosed |
| US-5416214-A | Use in fluorescent assay | SYNTEX (U.S.A.) INC. (US) | 1995-05-16 | — | — | US | disclosed |
| US-5329019-A | Squaraine dye compounds | SYNTEX (U.S.A.) INC. (US) | 1994-07-12 | — | — | US | disclosed |
| US-5310922-A | Squaraine dyes | SYNTEX (U.S.A.) INC. (US) | 1994-05-10 | — | — | US | disclosed |
| US-5039818-A | Squaraine dye | SYNTEX (U.S.A.) INC. (US) | 1991-08-13 | — | — | US | disclosed |
| US-4830786-A | CONDENSATION PRODUCT OF SQUARIC ACID WITH COMPOUNDS SUCH AS ANILINE | SYNTEX (U.S.A.) INC. (US) | 1989-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | FDFT1, COASY, HMGCR | NPSR1 972/4885HCAR2 225/4885GLO1 595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.