Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 17/20 | 0.48 |
| ▸ | DRD2 | P14416 | 10/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213144 | 0.86 | PDE3B (0.50) | DRD3DRD2KDRHTR1AADRB1 | |
| SCHEMBL214173 | 0.85 | DRD3 (0.49) | DRD3DRD2LTA4HHTR1AHTR1D | |
| SCHEMBL15938764 | 0.85 | LTA4H (0.57) | LTA4HKDR | |
| SCHEMBL216843 | 0.84 | LTA4H (0.44) | DRD3DRD2LTA4HHTR1AHTR1D | |
| SCHEMBL215485 | 0.80 | DRD3 (0.56) | DRD3DRD2LTA4HSIGMAR1 | |
| Bromide SCHEMBL214197 | 0.80 | CHEK2 (0.46) | — | |
| SCHEMBL10247571 | 0.77 | HRH3 (0.55) | LTA4H | |
| SCHEMBL15938763 | 0.76 | CHEK2 (0.56) | DRD3DRD2LTA4H | |
| SCHEMBL215889 | 0.74 | CYP3A4 (0.43) | KDR | |
| SCHEMBL6279659 | 0.73 | DRD3 (0.57) | DRD3DRD2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061768-A2 | IMIDAZOLE-4,5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | Exelixis, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008042282-A2 | IMIDAZOLE-4, 5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | EXELIXIS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |