Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SLC6A7 | Q99884 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1752967 | 0.81 | SLC6A7 (0.53) | CSNK1DMAPK14MAPTLMNASLC6A7 | |
| SCHEMBL27705074 | 0.79 | SLC6A7 (0.51) | CSNK1DMAPK14MAPTLMNASLC6A7 | |
| SCHEMBL12706599 | 0.76 | CSNK1D (0.54) | CSNK1DMAPK14MAPTLMNASLC6A7 | |
| SCHEMBL720267 | 0.74 | SLC6A7 (0.56) | CSNK1DMAPK14MAPTLMNASLC6A7 | |
| SCHEMBL29572108 | 0.74 | SLC6A7 (0.56) | CSNK1DMAPK14MAPTLMNASLC6A7 | |
| SCHEMBL1753162 | 0.72 | SLC6A7 (0.50) | CSNK1DMAPK14MAPTLMNASLC6A7 | |
| SCHEMBL1753129 | 0.72 | SLC6A7 (0.50) | CSNK1DMAPK14MAPTLMNASLC6A7 | |
| SCHEMBL1753150 | 0.71 | CSNK1D (0.52) | CSNK1DMAPK14MAPTLMNASLC6A7 | |
| SCHEMBL1753096 | 0.70 | CSNK1D (0.54) | CSNK1DMAPK14MAPTLMNASLC6A7 | |
| SCHEMBL1753210 | 0.70 | MAPT (0.49) | CSNK1DMAPK14MAPTLMNASLC6A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063894-A2 | FORMULATIONS CONTAINING PYRIDAZINE COMPOUNDS FOR TREATING NEUROINFLAMMATORY DISEASES | The Regents Of Northwestern University (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2007127375-A2 | FORMULATIONS CONTAINING PYRIDAZINE COMPOUNDS FOR TREATING NEUROINFLAMMATORY DISEASES | NORTHWESTERN UNIVERSITY (US) | 2007-11-08 | — | — | WO | disclosed |