Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 15/20 | 0.40 |
| ▸ | HSD11B2 | P80365 | 4/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4118605 | 0.84 | HSD11B1 (0.47) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL4121307 | 0.83 | HSD11B1 (0.45) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL4114874 | 0.83 | HSD11B1 (0.42) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL4117101 | 0.83 | HSD11B1 (0.42) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL4116886 | 0.80 | HSD11B1 (0.41) | HSD11B1HSD11B2EPHX2ALDH1A1MAPT | |
| SCHEMBL4108958 | 0.78 | HSD11B1 (0.47) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL4120245 | 0.78 | HSD11B1 (0.43) | HSD11B1HSD11B2EPHX2ALDH1A1MAPT | |
| SCHEMBL4113273 | 0.76 | HSD11B1 (0.40) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL4114112 | 0.76 | HSD11B1 (0.44) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL4132799 | 0.72 | HSD11B1 (0.36) | HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064187-A2 | INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | Vitae Pharmaceuticals, Inc. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008024497-A2 | INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE TYPE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2008-02-28 | — | — | WO | disclosed |