Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.67 |
| ▸ | AXL | P30530 | 5/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SGK1 | O00141 | 1/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.45 |
| ▸ | IL2 | P60568 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4119627 | 0.91 | AXL (0.61) | MAP4K1AXLMAPTHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4131847 | 0.87 | MAP4K1 (0.61) | MAP4K1AXLKCNH2CCNE2CCNE1 | |
| Hydrochloric Acid SCHEMBL4133749 | 0.86 | MAP4K1 (0.59) | MAP4K1AXLKCNH2CCNE2CCNE1 | |
| Hydrochloric Acid SCHEMBL4131354 | 0.84 | CCNE2 (0.58) | MAP4K1AXLKCNH2CCNE2CCNE1 | |
| SCHEMBL4119465 | 0.82 | MAP4K1 (0.51) | MAP4K1AXLPAK1PKN1CAMKK2 | |
| SCHEMBL30007360 | 0.82 | AXL (0.72) | AXLPAK1CYP2C19SGK1CAMKK2 | |
| SCHEMBL4121233 | 0.81 | MAP3K11 (0.67) | MAP4K1AXLCDK2 | |
| Hydrochloric Acid SCHEMBL4131246 | 0.81 | GSK3B (0.72) | MAP4K1CCNE2CCNE1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL4125840 | 0.81 | MAP4K1 (0.55) | MAP4K1CCNE2CCNE1CDK2GSK3B | |
| SCHEMBL4112313 | 0.80 | AXL (0.59) | MAP4K1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090018130-A1 | Derivatives of 5-Aryl-1H-Pyrrolo [2, 3B] Pyridine-3-Carboxamide or 5-Aryl-1H-Pyrrolo [2, 3B] Pyridine-3-Carboxylic Acid | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | US | claimed |
| US-20090018130-A1 | Derivatives of 5-Aryl-1H-Pyrrolo [2, 3B] Pyridine-3-Carboxamide or 5-Aryl-1H-Pyrrolo [2, 3B] Pyridine-3-Carboxylic Acid | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | US | disclosed |
| EP-1761530-A1 | NEW DERIVATIVES OF 5-ARYL-1H-PYRROLO [2, 3B] PYRIDINE-3-CARBOXAMIDE OR 5-ARYL-1H-PYRROLO [2, 3B] PYRIDINE-3-CARBOXYLIC ACID | AstraZeneca AB (SE) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006001754-A1 | NEW DERIVATIVES OF 5-ARYL-1H-PYRROLO [2, 3B] PYRIDINE-3-CARBOXAMIDE OR 5-ARYL-1H-PYRROLO [2, 3B] PYRIDINE-3-CARBOXYLIC ACID | ASTRAZENECA AB (SE) | 2006-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018130-A1 | Derivatives of 5-Aryl-1H-Pyrrolo [2, 3B] Pyridine-3-Carboxamide or 5-Aryl-1H-Pyrrolo [2, 3B] Pyridine-3-Carboxylic Acid | AADAC, PAH, PDE7A | MAP4K1 939/4885AXL 2020/4885KCNH2 868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.