Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 13/20 | 0.61 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.50 |
| ▸ | PTPRC | P08575 | 1/20 | 0.48 |
| ▸ | CD69 | Q07108 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3192642 | 0.92 | PTPN1 (0.66) | PTPN1PTPN2KMT2AMCL1PTPRC | |
| SCHEMBL4118782 | 0.83 | PTPN1 (0.61) | PTPN1PTPN2KMT2AMCL1PTPRC | |
| SCHEMBL3193527 | 0.80 | PTPN1 (0.64) | PTPN1PTPN2MCL1PTPRCCD69 | |
| SCHEMBL11844857 | 0.77 | PTPN1 (0.76) | PTPN1PTPN2KMT2AMCL1PTPRC | |
| SCHEMBL4136809 | 0.76 | KMT2A (0.53) | KMT2AMCL1 | |
| SCHEMBL3198156 | 0.76 | PTPN1 (1.00) | PTPN1PTPN2MCL1PTPRCCD69 | |
| SCHEMBL3729436 | 0.75 | KMT2A (1.00) | KMT2AMCL1CD69HIF1A | |
| SCHEMBL3194810 | 0.75 | PTPN1 (0.61) | PTPN1PTPN2KMT2APTPRC | |
| SCHEMBL13926043 | 0.73 | KDM4E (0.71) | PTPN1PTPN2KMT2APTPRCHIF1A | |
| SCHEMBL2897560 | 0.73 | MCL1 (0.52) | KMT2AMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | WYETH | 2005-09-15 | — | — | US | disclosed |
| WO-2005081960-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | PTPRS, PTPRO, PTPRM | PTPN1 11/4885PTPN2 23/4885KMT2A 2936/4885 |
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | PTPRS, PTPRO, PTPRM | PTPN1 11/4885PTPN2 23/4885KMT2A 2936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.