Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | FADS1 | O60427 | 1/20 | 0.45 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.44 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4121177 | 1.00 | MEN1 (0.59) | MEN1KMT2ARAB9AS1PR3MAPT | |
| SCHEMBL4108912 | 0.90 | S1PR3 (0.58) | MEN1KMT2ARAB9AS1PR3MAPT | |
| SCHEMBL4108910 | 0.90 | S1PR3 (0.58) | MEN1KMT2ARAB9AS1PR3MAPT | |
| SCHEMBL4109391 | 0.89 | MAPT (0.52) | MEN1KMT2ARAB9AMAPTLMNA | |
| SCHEMBL4109396 | 0.89 | MAPT (0.52) | MEN1KMT2ARAB9AMAPTLMNA | |
| SCHEMBL4104633 | 0.88 | S1PR3 (0.48) | MEN1KMT2ARAB9AS1PR3MAPT | |
| SCHEMBL4104630 | 0.88 | S1PR3 (0.48) | MEN1KMT2ARAB9AS1PR3MAPT | |
| SCHEMBL4115580 | 0.88 | MAPT (0.48) | MEN1KMT2ARAB9AS1PR3MAPT | |
| SCHEMBL4115574 | 0.88 | MAPT (0.48) | MEN1KMT2ARAB9AS1PR3MAPT | |
| SCHEMBL4125117 | 0.88 | MAPT (0.51) | MEN1KMT2ARAB9AS1PR3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546452-B2 | S1P3 receptor antagonist | TOA EIYO LTD. (JP) | 2013-10-01 | — | — | US | claimed |
| CN-101282926-B | S1p3 receptor antagonist | TOA EIYO LTD (JP) | 2011-07-13 | — | — | CN | claimed |
| US-20090170895-A1 | S1P3 RECEPTOR ANTAGONIST | TOA EIYO LTD. (JP) | 2009-07-02 | — | — | US | claimed |
| CN-101282926-A | S1p3 receptor antagonist | TOA EIYO LTD (JP) | 2008-10-08 | — | — | CN | claimed |
| EP-1935874-A1 | S1P3 RECEPTOR ANTAGONIST | TOA EIYO LTD. (JP) | 2008-06-25 | — | — | EP | claimed |
| US-20190117596-A1 | TY-52156 COMPOUNDS FOR THE TREATMENT OF CANCER | WAYNE STATE UNIVERSITY (US) | 2019-04-25 | — | — | US | disclosed |
| WO-2017190077-A1 | TY-52156 COMPOUNDS FOR THE TREATMENT OF CANCER | WAYNE STATE UNIVERSITY (US) | 2017-11-02 | — | — | WO | disclosed |
| US-8546452-B2 | S1P3 receptor antagonist | TOA EIYO LTD. (JP) | 2013-10-01 | — | — | US | disclosed |
| CN-101282926-B | S1p3 receptor antagonist | TOA EIYO LTD (JP) | 2011-07-13 | — | — | CN | disclosed |
| US-20090170895-A1 | S1P3 RECEPTOR ANTAGONIST | TOA EIYO LTD. (JP) | 2009-07-02 | — | — | US | disclosed |
| CN-101282926-A | S1p3 receptor antagonist | TOA EIYO LTD (JP) | 2008-10-08 | — | — | CN | disclosed |
| EP-1935874-A1 | S1P3 RECEPTOR ANTAGONIST | TOA EIYO LTD. (JP) | 2008-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190117596-A1 | TY-52156 COMPOUNDS FOR THE TREATMENT OF CANCER | S1PR3, S1PR1, S1PR4 | MEN1 1023/4885KMT2A 865/4885RAB9A 2012/4885 |
| US-20090170895-A1 | S1P3 RECEPTOR ANTAGONIST | S1PR3, S1PR5, GPR3 | MEN1 1287/4885KMT2A 2082/4885RAB9A 3324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.