⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4385710 | 0.86 | DPP4 (0.53) | — | |
| 2,5-Thiophenenedicarboxaldehyde SCHEMBL178830 | 0.80 | — | — | |
| SCHEMBL4061257 | 0.77 | PTGS1 (0.43) | — | |
| SCHEMBL4061262 | 0.77 | PTGS1 (0.43) | — | |
| SCHEMBL2014710 | 0.74 | — | — | |
| SCHEMBL1987243 | 0.74 | — | — | |
| SCHEMBL4207916 | 0.74 | — | — | |
| SCHEMBL31438618 | 0.74 | — | — | |
| SCHEMBL3165162 | 0.73 | PTGS1 (0.45) | — | |
| SCHEMBL3165155 | 0.73 | PTGS1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1002 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115754056-B | Method for detecting 5-chlorothiophene-2-formaldehyde | 乳源东阳光药业有限公司 | 2025-04-08 | — | — | CN | claimed |
| CN-117924275-A | (E) -2- (4-trifluoromethyl) -phenyl-6-cyclopropyl-5, 6,7, 8-tetrahydropyrido pyrimidine compound and synthesis and application thereof | 西华大学 | 2024-04-26 | — | — | CN | claimed |
| CN-117865956-A | 2-phenyl-4-furan or thiophene-substituted pyrimidopyridine derivative and synthesis and application thereof | 西华大学 | 2024-04-12 | — | — | CN | claimed |
| CN-117865959-A | 2- (4-fluoro) -phenyl-6-cyclopropyl-5, 6,7, 8-tetrahydropyrido pyrimidine derivative and synthesis and application thereof | 西华大学 | 2024-04-12 | — | — | CN | claimed |
| CN-116947754-A | Antitumor compound, antitumor drug, preparation method and application | 北京中医药大学 | 2023-10-27 | — | — | CN | claimed |
| CN-115754056-A | Method for detecting 5-chlorothiophene-2-formaldehyde | 乳源东阳光药业有限公司 | 2023-03-07 | — | — | CN | claimed |
| CN-115215854-A | Preparation process of efficient rivaroxaban bulk drug | 湖南恒生制药股份有限公司 | 2022-10-21 | — | — | CN | claimed |
| EP-3565552-B1 | AN IMPROVED PROCESS FOR THE PREPARATION OF RIVAROXABAN INVOLVING NOVEL INTERMEDIATE | UNICHEM LAB LTD (IN) | 2022-05-11 | — | — | EP | claimed |
| CN-109422720-B | Preparation method of low-cost and high-purity 5-chlorothiophene-2-formyl chloride | 新发药业有限公司 | 2021-07-20 | — | — | CN | claimed |
| CN-108840854-B | Method for synthesizing 5-chlorothiophene-2-carboxylic acid by one-pot method | 浙江扬帆新材料股份有限公司 | 2021-01-08 | — | — | CN | claimed |
| EP-1381359-A1 | AURONES AS TELOMERASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-01-21 | — | — | EP | claimed |
| EP-1324999-A1 | NOVEL AMINOPHENYL PIPERAZINE OR AMINOPHENYL PIPERIDINE DERIVATIVES INHIBITING PRENYL TRANSFERASE PROTEINS AND METHODS FOR PREPARING SAME | PIERRE FABRE MEDICAMENT (FR) | 2003-07-09 | — | — | EP | claimed |
| US-20030096796-A1 | Novel compounds and compositions as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2003-05-22 | — | — | US | claimed |
| JP-2002539191-A | — | — | 2002-11-19 | — | — | JP | claimed |
| WO-2002083123-A1 | AURONES AS TELOMERASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-10-24 | — | — | WO | claimed |
| US-6455502-B1 | Compounds and compositions as protease inhibitors | AXYS PHARMACEUTICALS, INC. | 2002-09-24 | — | — | US | claimed |
| WO-2002030927-A1 | NOVEL AMINOPHENYL PIPERAZINE OR AMINOPHENYL PIPERIDINE DERIVATIVES INHIBITING PRENYL TRANSFERASE PROTEINS AND METHODS FOR PREPARING SAME | PIERRE FABRE MEDICAMENT (FR) | 2002-04-18 | — | — | WO | claimed |
| EP-1178958-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-02-13 | — | — | EP | claimed |
| WO-2000055125-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | claimed |
| US-3960677-A | CARBOXY TERMINATED ANIONIC WETTING AGENT, FURAN, THIOPHENE, OR THIAZOLE BRIGHTNER | THE HARSHAW CHEMICAL COMPANY (US) | 1976-06-01 | — | — | US | claimed |