Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 7/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4119402 | 0.84 | RECQL (0.36) | MRGPRX4FDFT1LPAR1ABL1ALDH1A1 | |
| SCHEMBL4679921 | 0.83 | ALDH1A1 (0.43) | FDFT1LPAR1ALDH1A1MAPT | |
| SCHEMBL4111096 | 0.83 | ALDH1A1 (0.43) | FDFT1LPAR1ALDH1A1MAPT | |
| SCHEMBL4119367 | 0.83 | CYP3A4 (0.37) | FDFT1LPAR1ABL1ALDH1A1 | |
| SCHEMBL4129463 | 0.82 | GAA (0.34) | FDFT1LPAR1ABL1ALDH1A1MC4R | |
| SCHEMBL4111604 | 0.81 | MAPT (0.43) | FDFT1LPAR1ALDH1A1MAPT | |
| SCHEMBL4117287 | 0.80 | LPAR1 (0.39) | FDFT1LPAR1ALDH1A1MAPT | |
| SCHEMBL4122299 | 0.79 | TMPRSS4 (0.37) | MRGPRX4FDFT1 | |
| SCHEMBL4117534 | 0.79 | ALDH1A1 (0.40) | ALDH1A1MAPT | |
| SCHEMBL4119685 | 0.77 | FDFT1 (0.37) | FDFT1LPAR1ABL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| EP-1939205-A1 | TRICYCLIC COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2008-07-02 | — | — | EP | disclosed |
| EP-1939205-A1 | TRICYCLIC COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2008-07-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | FDFT1, COASY, HMGCR | MRGPRX4 2909/4885FDFT1 1/4885LPAR1 345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.