Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylthiouracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPO known ✓ | P07202 | 1/20 | 1.00 |
| ▸ | LPO | P22079 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | MPO | P05164 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | TAS2R38 | P59533 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 10/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYB5R3 | P00387 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylthiouracil SCHEMBL5493716 | 1.00 | LPO (1.00) | LPOCYP2C19MPOTPOTSHR | |
| Propylthiouracil SCHEMBL27995248 | 0.98 | LPO (0.96) | LPOCYP2C19MPOTPOTSHR | |
| Propylthiouracil SCHEMBL13723721 | 0.91 | LPO (0.83) | LPOCYP2C19MPOTPOTSHR | |
| SCHEMBL8407853 | 0.89 | KMT2A (0.90) | LPOCYP2C19MPOTPOTSHR | |
| Propylthiouracil SCHEMBL2322792 | 0.87 | CYP2C19 (0.76) | LPOCYP2C19MPOTPOTSHR | |
| SCHEMBL10489579 | 0.87 | KMT2A (1.00) | LPOCYP2C19MPOTPOTSHR | |
| Propylthiouracil SCHEMBL20771755 | 0.86 | LPO (0.73) | LPOCYP2C19MPOTPOTSHR | |
| SCHEMBL11739128 | 0.85 | KMT2A (0.97) | LPOCYP2C19MPOTPOTSHR | |
| SCHEMBL29948466 | 0.85 | KMT2A (0.97) | LPOCYP2C19MPOTPOTSHR | |
| SCHEMBL15752987 | 0.85 | KMT2A (0.97) | LPOCYP2C19MPOTPOTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 15751 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4748438-A2 | ENTERICALLY DELIVERED BITTER OLIGOPEPTIDES FOR THE TREATMENT FOR TYPE 2 DIABETES | Cedars-Sinai Medical Center (US) | 2026-05-27 | — | — | EP | claimed |
| CN-122074448-A | Progressive pathological animal model for drug evaluation and construction method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-119237105-B | Recovery processing equipment of propylthiouracil | 精华制药集团南通有限公司 | 2026-05-15 | — | — | CN | claimed |
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| CN-224221364-U | Propoxopyrimidine intermediate synthesis device | 精华制药集团南通有限公司 | 2026-05-12 | — | — | CN | claimed |
| WO-2026087745-A1 | AN ANTIOXIDANT COMPOSITION COMPRISING A CINNAMIC ACID DERIVATIVE | BRAIN Biotech AG (DE) | 2026-04-30 | — | — | WO | claimed |
| EP-4732825-A1 | AN ANTIOXIDANT COMPOSITION COMPRISING A CINNAMIC ACID DERIVATIVE | BRAIN Biotech AG (DE) | 2026-04-29 | — | — | EP | claimed |
| EP-4194001-B1 | ENTERICALLY DELIVERED BITTER OLIGOPEPTIDES FOR THE TREATMENT OF TYPE 2 DIABETES AND OBESITY | CEDARS SINAI MEDICAL CENTER (US) | 2026-03-18 | — | — | EP | claimed |
| EP-3256094-B1 | DENTAL COMPOSITIONS AND METHODS OF USE | ZEST IP HOLDINGS LLC (US) | 2026-01-07 | — | — | EP | claimed |
| US-20250312457-A1 | PHARMACEUTICAL COMPOSITIONS OF ROFLUMILAST IN AQUEOUS BLENDS OF WATER-MISCIBLE, PHARMACEUTICALLY ACCEPTABLE SOLVENTS | ARCUTIS BIOTHERAPEUTICS INC (US) | 2025-10-09 | — | — | US | claimed |
| WO-1994028897-A2 | USE OF AN MHC CLASS I SUPPRESSOR DRUG FOR THE TREATMENT OF AUTOIMMUNE DISEASES AND TRANSPLANTATION REJECTION | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1994-12-22 | — | — | WO | claimed |
| WO-1994023700-A1 | HIGH RELEASE SOLID PREPARATION, PREPARATION AND USE THEREOF | RIJKSUNIVERSITEIT GENT LABORATORIUM VOOR FARMACEUTISCHE TECHNOLOGIE (BE) | 1994-10-27 | — | — | WO | claimed |
| WO-1994012183-A1 | USE OF THIOURELEYLENES AND THIABENDAZOLE IN AUTOIMMUNE DISEASES | ELIAS ALAN N (US) | 1994-06-09 | — | — | WO | claimed |
| US-5310742-A | Uses for thioureylenes | ELIAS ALAN N (US) | 1994-05-10 | — | — | US | claimed |
| CN-1085079-A | Antithyroid cream for external application | CHEN LING (CN) | 1994-04-13 | — | — | CN | claimed |
| CN-1084078-A | Antithyroid cream for external application | CHEN LING (CN) | 1994-03-23 | — | — | CN | claimed |
| WO-1993008801-A1 | PREVENTION OF DRUG-INDUCED AGRANULOCYTOSIS WITH FREE RADICAL SCAVENGERS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1993-05-13 | — | — | WO | claimed |
| US-4952402-A | EDIBLE TASTE-MASKED DRUGS; MICROMATRIX ACTIVE MATERIAL COATED WITH NONTOXIC POLYMER; LIQUIDS; TABLETS | ELAN CORPORATION, P.L.C. (IE) | 1990-08-28 | — | — | US | claimed |
| US-4526857-A | Processing photosensitive element provided with layer of photosensitive silver halide emulsion and layer of image receiving element containing 1,2,4-triazole with composition comprising alkali, hydroxylamine, solvent | FUJI PHOTO FILM CO., LTD. (JP) | 1985-07-02 | — | — | US | claimed |
| US-4369172-A | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose | FOREST LABORATORIES INC. (US) | 1983-01-18 | — | — | US | claimed |