SCHEMBL4124381

SCHEMBL4124381

COc1cccc(C(=O)O)c1C(C)C

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.56
HTT P42858 1/20 0.54
CA12 O43570 1/20 0.53
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
CA7 P43166 1/20 0.53
CA9 Q16790 1/20 0.53
CA14 Q9ULX7 1/20 0.53
HPGD P15428 6/20 0.50
ALDH1A1 P00352 4/20 0.50
HSD17B10 Q99714 3/20 0.50
KCNK3 O14649 2/20 0.49
KCNK9 Q9NPC2 2/20 0.49
KMT2A Q03164 2/20 0.47
CDC25B P30305 2/20 0.47
FABP3 P05413 1/20 0.47
FABP4 P15090 1/20 0.47
FABP5 Q01469 1/20 0.47
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11611618 0.84 HTT (0.53) KDM4EHTTCA12CA1CA2
SCHEMBL5428398 0.84 KDM4E (0.51) KDM4EHTTCA12CA1CA2
SCHEMBL381131 0.84 IRAK4 (0.53) KDM4EHTTCA12CA1CA2
SCHEMBL19026799 0.84 KDM4E (0.51) KDM4EHTTCA12CA1CA2
SCHEMBL28984371 0.83 KDM4E (0.44) KDM4EHTTCA12CA1CA2
SCHEMBL3389839 0.82 ALDH1A1 (0.52) KDM4ECA12CA1CA2CA7
SCHEMBL27515327 0.80 KDM4E (0.41) KDM4EHTTCA12CA1CA2
Acrylic Acid SCHEMBL28021135 0.79 KDM4E (0.65) KDM4EHTTCA12CA1CA2
Propionic Acid SCHEMBL27946489 0.79 KDM4E (0.56) KDM4EHTTCA12CA1CA2
Methyl Alcohol SCHEMBL27577395 0.78 KDM4E (0.54) KDM4ECA12CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105037590-A Propylene-based polymer and process for producing same GRACE W R & CO 2015-11-11 CN disclosed
CN-102741341-B Propylene impact copolymers and process DOW GLOBAL TECHNOLOGIES LLC (US) 2015-08-05 CN disclosed
CN-102482376-B Propylene random copolymer compositions, articles and methods DOW GLOBAL TECHNOLOGIES INC (US) 2014-04-02 CN disclosed
CN-102333796-B Propylene-based polymer, articles, and process for producing same DOW GLOBAL TECHNOLOGIES INC (US) 2013-12-11 CN disclosed
CN-102741341-A Propylene impact copolymers and process DOW GLOBAL TECHNOLOGIES INC (US) 2012-10-17 CN disclosed
CN-102482376-A Propylene random copolymer compositions, articles and methods DOW GLOBAL TECHNOLOGIES INC (US) 2012-05-30 CN disclosed
CN-102333796-A Propylene-based polymer, articles, and process for producing same DOW GLOBAL TECHNOLOGIES INC (US) 2012-01-25 CN disclosed
US-20090181942-A1 TRICYCLIC COMPOUNDS DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-07-16 US disclosed
EP-1939205-A1 TRICYCLIC COMPOUND Daiichi Sankyo Company, Limited (JP) 2008-07-02 EP disclosed
CN-1167670-C Aryl carboxylic acid and tetrazole derivant - 2004-09-22 CN disclosed
EP-1013639-B1 Aryl carboxylic acid and tetrazole derivatives comprising a carbamoyloxy unit HOFFMANN LA ROCHE (CH) 2003-10-01 EP disclosed
US-6335459-B1 PROSTAGLANDIN I2 RECEPTOR MODULATORS; TREATING TISSUE NECROSIS, PREMATURE UTERINE CONTRACTION, GASTRIC ULCERATION, SEXUAL DYSFUNCTION, MENSTRUAL PAIN AND IMPROPER WOUND HEALING, IMMUNOREGULATION, PLATELET AGGREGATION OR NEUTROPHIL FUNCTION SYNTEX (U.S.A.) LLC 2002-01-01 US disclosed
CN-1072217-C Insecticidal N'-substituted -N, N'-diacylhydrazines ROHM & HAAS (US) 2001-10-03 CN disclosed
CN-1266054-A Aryl carboxylic acid and tetrazole derivant HOFFMANN LA ROCHE (CH) 2000-09-13 CN disclosed
EP-1013639-A1 Aryl carboxylic acid and tetrazole derivatives comprising a carbamoyloxy unit F. HOFFMANN-LA ROCHE AG (CH) 2000-06-28 EP disclosed
EP-0602794-B1 Insecticidal N'-substituted-N, N'-diacylhydrazines ROHM & HAAS (US) 1999-04-21 EP disclosed
EP-0729953-A2 A process for producing a 2-substituted-3,4-fused heterocyclic benzoic acid ROHM AND HAAS COMPANY (US) 1996-09-04 EP disclosed
EP-0729934-A2 A process for producing a 3-alkoxy-2-(substituted)benzoic acid or an ester thereof ROHM AND HAAS COMPANY (US) 1996-09-04 EP disclosed
US-5530028-A CONTROLS INSECTS OF THE ORDER LEPIDOPTERA ROHM AND HAAS COMPANY (US) 1996-06-25 US disclosed
EP-0602794-A2 Insecticidal N'-substituted-N, N'-diacylhydrazines ROHM AND HAAS COMPANY (US) 1994-06-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090181942-A1 TRICYCLIC COMPOUNDS FDFT1, COASY, HMGCR KDM4E 2123/4885HTT 1777/4885CA12 4701/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.