Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNTT | P04053 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | TLR4 | O00206 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29329319 | 0.89 | CYP1A2 (0.36) | DNTTCYP1A2HIF1AKDM4EALDH1A1 | |
| SCHEMBL5254413 | 0.83 | TSHR (0.34) | DNTTCYP1A2HIF1ATLR4KDM4E | |
| SCHEMBL4123910 | 0.79 | FKBP1A (0.40) | CYP1A2KDM4EHSD17B10ALDH1A1FKBP1A | |
| SCHEMBL3813382 | 0.79 | KDM4E (0.37) | CYP1A2HIF1AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4128790 | 0.79 | CYP1A2 (0.36) | DNTTCYP1A2HIF1AKDM4EHSD17B10 | |
| SCHEMBL22309984 | 0.78 | CYP1A2 (0.35) | DNTTCYP1A2HIF1AKDM4EHSD17B10 | |
| SCHEMBL3339309 | 0.77 | CYP1A2 (0.37) | CYP1A2HIF1AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL3399318 | 0.76 | CYP1A2 (0.36) | CYP1A2HIF1AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL3236730 | 0.73 | CYP1A2 (0.37) | CYP1A2HIF1AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4121606 | 0.72 | CYP1A2 (0.36) | CYP1A2HIF1AKDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436005-B2 | Macrocyclic pyrimidine derivatives | ABBOTT LABORATORIES (US) | 2013-05-07 | — | — | US | disclosed |
| US-20090253678-A1 | MACROCYCLIC PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253678-A1 | MACROCYCLIC PYRIMIDINE DERIVATIVES | DPYD, TYMS, TYMP | DNTT 360/4885CYP1A2 1655/4885HIF1A 1898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.