Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5264108 | 1.00 | KDM4E (0.57) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| Trifluoroacetic Acid SCHEMBL4125561 | 1.00 | KDM4E (0.57) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| Trifluoroacetic Acid SCHEMBL4146945 | 0.87 | KDM4E (0.39) | KDM4ESMN1; SMN2CYP1A2LMNAGSK3B | |
| Trifluoroacetic Acid SCHEMBL4142668 | 0.85 | KDM4E (0.56) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| Trifluoroacetic Acid SCHEMBL4142666 | 0.85 | KDM4E (0.56) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| Trifluoroacetic Acid SCHEMBL4125521 | 0.82 | KDM4E (0.61) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| Trifluoroacetic Acid SCHEMBL4125523 | 0.82 | KDM4E (0.61) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| SCHEMBL4143494 | 0.82 | KDM4E (0.52) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| SCHEMBL4143498 | 0.82 | KDM4E (0.52) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| Trifluoroacetic Acid SCHEMBL4127958 | 0.81 | KDM4E (0.59) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111760-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111760-A1 | MACROLONE COMPOUNDS | CYP51A1, MRPL21, MYD88 | KDM4E 3897/4885SMN1; SMN2 2560/4885CYP1A2 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.