Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5264108 | 0.87 | KDM4E (0.57) | KDM4ESMN1; SMN2CYP1A2LMNAALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4125561 | 0.87 | KDM4E (0.57) | KDM4ESMN1; SMN2CYP1A2LMNAALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4125556 | 0.87 | KDM4E (0.57) | KDM4ESMN1; SMN2CYP1A2LMNAALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL3976871 | 0.85 | KDM4E (0.38) | KDM4ESMN1; SMN2CYP1A2LMNAADRA2B | |
| SCHEMBL4134781 | 0.79 | DDB1 (0.40) | KDM4ESMN1; SMN2CYP1A2GSK3BHRH3 | |
| SCHEMBL4134055 | 0.77 | KDM4E (0.39) | KDM4ESMN1; SMN2CYP1A2LMNAADRA2B | |
| Trifluoroacetic Acid SCHEMBL4164839 | 0.77 | KDM4E (0.35) | KDM4ESMN1; SMN2CYP1A2ADRA2BMAPK1 | |
| SCHEMBL5435573 | 0.74 | SIGMAR1 (0.40) | KDM4ESMN1; SMN2CYP1A2ADRA2BMAPK1 | |
| Trifluoroacetic Acid SCHEMBL3819895 | 0.74 | KDM4E (0.52) | KDM4ECYP1A2LMNAMAPK1ALDH1A1 | |
| SCHEMBL5433734 | 0.73 | SIGMAR1 (0.40) | KDM4ESMN1; SMN2CYP1A2ADRA2BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111760-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111760-A1 | MACROLONE COMPOUNDS | CYP51A1, MRPL21, MYD88 | KDM4E 3897/4885SMN1; SMN2 2560/4885CYP1A2 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.