SCHEMBL4125580

SCHEMBL4125580

CC(=O)OCc1ccc(-c2ccc(C=C3SC(Nc4ccc([Na])cc4)=NC3=O)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 13/20 0.41
MYC P01106 1/20 0.39
MAX P61244 1/20 0.39
MEN1 O00255 5/20 0.39
KMT2A Q03164 5/20 0.39
MAPT P10636 4/20 0.39
MITF O75030 3/20 0.39
HPGD P15428 3/20 0.39
CYP1A2 P05177 2/20 0.39
CYP2C9 P11712 2/20 0.39
CYP2C19 P33261 2/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
CISD1 Q9NZ45 1/20 0.38
ALDH1A1 P00352 2/20 0.37
LMNA P02545 1/20 0.37
RAB9A P51151 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL4125584 0.86 MYC (0.41) ALOX5MYCMAXMEN1KMT2A
Acetic Acid SCHEMBL4123820 0.83 ALOX5 (0.44) ALOX5MEN1KMT2AMAPTALDH1A1
Acetic Acid SCHEMBL4133460 0.83 ALOX5 (0.53) ALOX5MEN1KMT2AMAPTHPGD
Acetic Acid SCHEMBL4133456 0.83 ALOX5 (0.53) ALOX5MEN1KMT2AMAPTHPGD
Acetic Acid SCHEMBL4635017 0.82 ALOX5 (0.55) ALOX5
Acetic Acid SCHEMBL4137023 0.82 ALOX5 (0.55) ALOX5
Acetic Acid SCHEMBL4128829 0.82 ALOX5 (0.46) ALOX5MEN1KMT2AMAPTCISD1
Acetic Acid SCHEMBL4122564 0.82 MAPT (0.47) ALOX5MEN1KMT2AMAPTCISD1
Acetic Acid SCHEMBL4122563 0.82 MAPT (0.47) ALOX5MEN1KMT2AMAPTCISD1
Acetic Acid SCHEMBL4128774 0.82 ALOX5 (0.53) ALOX5MEN1KMT2AMAPTMITF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090088432-A1 Thiazolinones and Oxazolinones and their Use as Ptp1b Inhibitors TORRENT PHARMACEUTICALS LIMITED (IN) 2009-04-02 US claimed
US-20090088432-A1 Thiazolinones and Oxazolinones and their Use as Ptp1b Inhibitors TORRENT PHARMACEUTICALS LIMITED (IN) 2009-04-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090088432-A1 Thiazolinones and Oxazolinones and their Use as Ptp1b Inhibitors PTPRF, PTPA, PTPRJ ALOX5 3505/4885MYC 2793/4885MAX 4458/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.