Citric Acid

Citric Acid

SCHEMBL4126025

O=C(O)CC(O)(CC(=O)O)C(=O)O.OCCCCCCCCCCCCO

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.39
ALDH1A1 P00352 2/20 0.71
FFAR1 O14842 2/20 0.48
GPR84 Q9NQS5 1/20 0.48
FFAR4 Q5NUL3 1/20 0.48
CAMK2A Q9UQM7 1/20 0.40
KDM4E B2RXH2 2/20 0.39
LMNA P02545 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
KMT2A Q03164 1/20 0.39
HMGCR P04035 1/20 0.39
CHRM1 P11229 1/20 0.39
TBXA2R P21731 1/20 0.39
ADRA1A P35348 1/20 0.39
CPT2 P23786 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
ACLY P53396 1/20 0.38
MAPT P10636 1/20 0.38
ALOX15 P16050 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL427468 1.00 ALDH1A1 (0.71) ALDH1A1FFAR1GPR84FFAR4CAMK2A
Citric Acid SCHEMBL29176427 1.00 ALDH1A1 (0.71) ALDH1A1FFAR1GPR84FFAR4CAMK2A
Citric Acid SCHEMBL429703 1.00 ALDH1A1 (0.71) ALDH1A1FFAR1GPR84FFAR4CAMK2A
Citric Acid SCHEMBL1550228 1.00 ALDH1A1 (0.71) ALDH1A1FFAR1GPR84FFAR4CAMK2A
Citric Acid SCHEMBL423249 1.00 ALDH1A1 (0.71) ALDH1A1FFAR1GPR84FFAR4CAMK2A
Citric Acid SCHEMBL427796 1.00 ALDH1A1 (0.71) ALDH1A1FFAR1GPR84FFAR4CAMK2A
Citric Acid SCHEMBL29176408 1.00 ALDH1A1 (0.71) ALDH1A1FFAR1GPR84FFAR4CAMK2A
Citric Acid SCHEMBL426066 0.98 ALDH1A1 (0.75) ALDH1A1FFAR1GPR84FFAR4CAMK2A
Citric Acid SCHEMBL16796011 0.98 ALDH1A1 (0.75) ALDH1A1FFAR1GPR84FFAR4CAMK2A
Citric Acid SCHEMBL426261 0.93 ALDH1A1 (0.75) ALDH1A1FFAR1GPR84FFAR4CAMK2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12214104-B2 Photo-reactive inks and thermal-curable materials made therefrom NORTHWESTERN UNIVERSITY (US) 2025-02-04 US disclosed
US-20240009357-A1 3D PRINTING OF BIOMEDICAL IMPLANTS NORTHWESTERN UNIVERSITY 2024-01-11 US disclosed
US-11565026-B2 3D printing of biomedical implants NORTHWESTERN UNIVERSITY (US) 2023-01-31 US disclosed
CN-215384892-U Myocardial patch with microneedle 宁波迪创医疗科技有限公司 2022-01-04 CN disclosed
CN-113069241-A Myocardial patch with microneedle 宁波迪创医疗科技有限公司 2021-07-06 CN disclosed
EP-1988847-B1 FUNCTIONALIZING IMPLANTABLE DEVICES WITH A POLY (DIOL-CO-CITRATE) POLYMER UNIV NORTHWESTERN (US) 2014-08-13 EP disclosed
US-20090148945-A1 Novel Biodegradable Elastomeric Scaffold for Tissue Engineering and Light Scattering Fingerprinting Methods for Testing the Same NORTHWESTERN UNIVERSITY (US) 2009-06-11 US disclosed
EP-1988847-A2 FUNCTIONALIZING IMPLANTABLE DEVICES WITH A POLY (DIOL-CO-CITRATE) POLYMER NORTHWESTERN UNIVERSITY (US) 2008-11-12 EP disclosed
WO-2007092559-A2 A POLY (DIOL-CO-CITRATE) HYDROXYAPATITE COMPOSITE FOR TISSUE ENGINEERING AND ORTHOPAEDIC FIXATION DEVICES NORTHWESTERN UNIVERSITY (US) 2007-08-16 WO disclosed
WO-2007092583-A2 FUNCTIONALIZING IMPLANTABLE DEVICES WITH A POLY (DIOL-CO-CITRATE) POLYMER NORTHWESTERN UNIVERSITY (US) 2007-08-16 WO disclosed
WO-2007038625-A2 BIODEGRADABLE NANOCOMPOSITES WITH ENHANCED MECHANICAL PROPERTIES FOR SOFT TISSUE ENGINEERING. NORTHWESTERN UNIVERSITY (US) 2007-04-05 WO disclosed
WO-2005028631-A2 A NOVEL BIODEGRADABLE ELASTOMERIC SCAFFOLD FOR TISSUE ENGINEERING AND LIGHT SCATTERING FINGERPRINTING METHODS FOR TESTING THE SAME NORTHWESTERN UNIVERSITY (US) 2005-03-31 WO disclosed