Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 18/20 | 0.57 |
| ▸ | PDE2A | O00408 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4125509 | 0.88 | PDE10A (0.75) | PDE10APDE2APDE5APDE3APDE11A | |
| SCHEMBL3661859 | 0.83 | PDE10A (0.41) | PDE10APDE2APDE5APDE3APDE11A | |
| SCHEMBL4127697 | 0.82 | PDE10A (0.52) | PDE10APDE2APDE5APDE3APDE11A | |
| SCHEMBL3654534 | 0.74 | PDE10A (0.48) | PDE10APDE2APDE5APDE3APDE11A | |
| SCHEMBL13816961 | 0.74 | PDE10A (1.00) | PDE10APDE2APDE5APDE3APDE11A | |
| SCHEMBL3658808 | 0.74 | PDE10A (0.43) | PDE10APDE2APDE5APDE3APDE11A | |
| SCHEMBL4129519 | 0.74 | HCAR1 (0.44) | PDE10APDE2APDE5APDE3APDE11A | |
| SCHEMBL4113074 | 0.71 | PDE10A (0.47) | PDE10APDE2APDE5APDE3APDE11A | |
| SCHEMBL3657346 | 0.70 | PDE10A (0.53) | PDE10APDE2A | |
| SCHEMBL972747 | 0.69 | PDE10A (0.51) | PDE10APDE2AACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070583-A1 | PYRIDO[3,2-E]PYRAZINES, PROCESS FOR PREPARING THE SAME, AND THEIR USE AS INHIBITORS OF PHOSPHODIESTERASE 10 | WYETH (US) | 2009-06-04 | — | — | WO | claimed |
| US-20090143361-A1 | Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10 | ELBION GMBH (DE) | 2009-06-04 | — | — | US | claimed |
| US-20090143361-A1 | Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10 | ELBION GMBH (DE) | 2009-06-04 | — | — | US | disclosed |
| US-20090143361-A1 | Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10 | ELBION GMBH (DE) | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143361-A1 | Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10 | PDE12, PDE5A, PDE3A | PDE10A 10/4885PDE2A 4/4885PDE5A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.