Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3553955 | 0.86 | HSD11B1 (0.64) | HSD11B1LMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL2998476 | 0.84 | HSD11B1 (0.54) | HSD11B1TP53ALDH1A1KMT2A | |
| SCHEMBL209343 | 0.84 | HSD11B1 (0.54) | HSD11B1TP53MEN1ALDH1A1KMT2A | |
| SCHEMBL208406 | 0.81 | HSD11B1 (0.51) | HSD11B1MEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL2988725 | 0.79 | HSD11B1 (0.59) | HSD11B1LMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL2988726 | 0.79 | HSD11B1 (0.59) | HSD11B1LMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL2997277 | 0.79 | HSD11B1 (0.55) | HSD11B1TP53LMNAMEN1KMT2A | |
| SCHEMBL2990265 | 0.79 | HSD11B1 (0.59) | HSD11B1LMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL3002320 | 0.78 | HSD11B1 (0.57) | HSD11B1LMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL3546132 | 0.78 | HSD11B1 (0.51) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-B1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2009-01-07 | — | — | EP | claimed |