Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.59 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTR5A | P47898 | 1/20 | 0.45 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31020972 | 1.00 | SIRT2 (0.60) | SIRT2TAAR1NISCHADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL31020957 | 0.98 | TAAR1 (0.62) | SIRT2TAAR1NISCHADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL23828316 | 0.98 | TAAR1 (0.62) | SIRT2TAAR1NISCHADRA2AADRA2B | |
| SCHEMBL25512897 | 0.89 | HTR2A (0.60) | SIRT2TAAR1NISCHADRA2AADRA2B | |
| SCHEMBL2980946 | 0.87 | NISCH (0.67) | SIRT2TAAR1NISCHADRA2AADRA2B | |
| SCHEMBL2980510 | 0.87 | SIRT2 (0.72) | SIRT2TAAR1RAD52KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL11840237 | 0.86 | SIRT2 (0.71) | SIRT2TAAR1RAD52KMT2AKDM4E | |
| SCHEMBL20883910 | 0.81 | TAAR1 (0.56) | SIRT2TAAR1NISCHADRA2AADRA2B | |
| SCHEMBL21676105 | 0.81 | TAAR1 (0.56) | SIRT2TAAR1NISCHADRA2AADRA2B | |
| SCHEMBL18345852 | 0.81 | TAAR1 (0.59) | SIRT2TAAR1NISCHADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820867-B1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS | FONDAZIONE ST ITALIANO TECNOLOGIA (IT) | 2023-09-13 | — | — | EP | disclosed |
| US-20210292324-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS | ISTITUTO GIANNINA GASLINI (IT) | 2021-09-23 | — | — | US | disclosed |
| WO-2020012427-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2020-01-16 | — | — | WO | disclosed |
| WO-2019074979-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | GIRAFPHARMA, LLC (US) | 2019-04-18 | — | — | WO | disclosed |
| WO-2014155300-A2 | SUBSTITUED PYRIMIDINE AMINE DERIVATIVES AS TAK-1 INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-10-02 | — | — | WO | disclosed |
| US-20090023756-A1 | SUBSTITUTED QUINAZOLINES AS PDE10 INHIBITORS | PFIZER INC | 2009-01-22 | — | — | US | disclosed |
| US-20090023756-A1 | SUBSTITUTED QUINAZOLINES AS PDE10 INHIBITORS | PFIZER INC | 2009-01-22 | — | — | US | disclosed |
| US-20090023756-A1 | SUBSTITUTED QUINAZOLINES AS PDE10 INHIBITORS | PFIZER INC | 2009-01-22 | — | — | US | disclosed |
| WO-2007096743-A1 | SUBSTITUTED QUINAZOLINES AS PDE10 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2007-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023756-A1 | SUBSTITUTED QUINAZOLINES AS PDE10 INHIBITORS | PDE12, PDE5A, PDE10A | SIRT2 1258/4885TAAR1 1031/4885NISCH 1594/4885 |
| US-20210292324-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, ABCB11, ABCC5 | SIRT2 3850/4885TAAR1 3882/4885NISCH 386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.