Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 8/20 | 0.59 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PTPRC | P08575 | 1/20 | 0.45 |
| ▸ | SENP5 | Q96HI0 | 2/20 | 0.45 |
| ▸ | SENP2 | Q9HC62 | 2/20 | 0.45 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MDH2 | P40926 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9375405 | 0.85 | EDNRA (0.58) | EDNRAALDH1A1KDM4ESENP5SENP2 | |
| SCHEMBL4135388 | 0.83 | PTPN1 (0.53) | EDNRAPTPN1PTPN2ALDH1A1KDM4E | |
| SCHEMBL15211382 | 0.80 | NR4A2 (0.53) | PTPN1PTPN2ALDH1A1PPARGNR4A2 | |
| SCHEMBL4125811 | 0.80 | PTPN1 (0.55) | PTPN1PTPN2PTPRC | |
| SCHEMBL11844857 | 0.79 | PTPN1 (0.76) | PTPN1PTPN2ALDH1A1KDM4EPTPRC | |
| SCHEMBL4634967 | 0.79 | EDNRA (0.54) | EDNRAPTPN1PTPN2ALDH1A1KDM4E | |
| SCHEMBL4126003 | 0.79 | EDNRA (0.47) | EDNRAPTPN1KDM4ESENP5SENP2 | |
| SCHEMBL4119836 | 0.78 | PTPN1 (0.51) | PTPN1PTPN2SENP5SENP2SENP1 | |
| SCHEMBL4634951 | 0.78 | KDM4E (0.67) | EDNRAPTPN1PTPN2ALDH1A1KDM4E | |
| SCHEMBL4126226 | 0.77 | PTPN1 (0.52) | PTPN1PTPN2PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | WYETH | 2005-09-15 | — | — | US | disclosed |
| WO-2005081960-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | PTPRS, PTPRO, PTPRM | EDNRA 3588/4885PTPN1 11/4885PTPN2 23/4885 |
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | PTPRS, PTPRO, PTPRM | EDNRA 3588/4885PTPN1 11/4885PTPN2 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.