Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | SENP2 | Q9HC62 | 10/20 | 0.49 |
| ▸ | SENP1 | Q9P0U3 | 10/20 | 0.49 |
| ▸ | SENP5 | Q96HI0 | 9/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4119525 | 0.89 | NPC1 (0.50) | PTPN1PTPN2HDAC1PTGS2 | |
| SCHEMBL4120451 | 0.84 | SENP5 (0.49) | PTPN1PTPN2SENP2SENP1SENP5 | |
| SCHEMBL4126550 | 0.83 | HDAC1 (0.47) | HDAC1SENP2SENP1SENP5CYP2D6 | |
| SCHEMBL4135388 | 0.80 | PTPN1 (0.53) | PTPN1PTPN2 | |
| SCHEMBL4127309 | 0.80 | PTPN1 (0.49) | PTPN1PTPN2 | |
| SCHEMBL4120133 | 0.80 | PTPN1 (0.49) | PTPN1PTPN2 | |
| SCHEMBL4119518 | 0.80 | DYRK1A (0.51) | PTPN1PTPN2HDAC1 | |
| SCHEMBL11844857 | 0.79 | PTPN1 (0.76) | PTPN1PTPN2 | |
| SCHEMBL4126773 | 0.78 | EDNRA (0.59) | PTPN1PTPN2SENP2SENP1SENP5 | |
| SCHEMBL30607029 | 0.78 | HDAC1 (0.61) | HDAC1CYP2D6CYP2C9CYP2C19PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | WYETH | 2005-09-15 | — | — | US | disclosed |
| WO-2005081960-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | PTPRS, PTPRO, PTPRM | PTPN1 11/4885PTPN2 23/4885HDAC1 1382/4885 |
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | PTPRS, PTPRO, PTPRM | PTPN1 11/4885PTPN2 23/4885HDAC1 1382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.