Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.56 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.55 |
| ▸ | MTOR | P42345 | 5/20 | 0.55 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.52 |
| ▸ | AKT1 | P31749 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10327822 | 0.91 | BRAF (0.55) | BRAFPIK3CAMTORPIK3R1JAK2 | |
| SCHEMBL4127408 | 0.89 | PIK3CA (0.59) | PIK3CAMAP3K12MTORPIK3R1PIK3CG | |
| SCHEMBL4110129 | 0.85 | PIK3CA (0.57) | PIK3CAMAP3K12MTORPIK3R1PIK3CG | |
| SCHEMBL10327811 | 0.83 | PIK3CA (0.69) | PIK3CAMAP3K12MTORPIK3R1PIK3CG | |
| SCHEMBL3995830 | 0.83 | PIK3CA (0.56) | PIK3CAMAP3K12MTORPIK3R1PIK3CG | |
| SCHEMBL3994767 | 0.83 | PIK3CA (0.61) | PIK3CAMAP3K12MTORPIK3R1PIK3CG | |
| SCHEMBL10327854 | 0.82 | PIK3CA (0.65) | BRAFPIK3CAMTORPIK3R1PIK3CG | |
| SCHEMBL1311325 | 0.80 | PIK3CA (0.64) | BRAFPIK3CAMTORPIK3CG | |
| SCHEMBL13848122 | 0.80 | PIK3CA (0.72) | PIK3CAMAP3K12MTORPIK3R1PIK3CD | |
| SCHEMBL7900675 | 0.79 | PIK3CA (0.61) | BRAFPIK3CAMTORPIK3R1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | claimed |