Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.61 |
| ▸ | PIK3R1 | P27986 | 10/20 | 0.61 |
| ▸ | MTOR | P42345 | 4/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | JAK1 | P23458 | 1/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7902204 | 0.84 | PIK3CA (0.76) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL4127804 | 0.79 | BRAF (0.56) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL7902806 | 0.78 | PIK3CA (0.67) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL7894820 | 0.77 | PIK3CA (0.71) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| Vs-5584 SCHEMBL539098 | 0.77 | PIK3CA (1.00) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| Vs-5584 SCHEMBL29376859 | 0.77 | PIK3CA (1.00) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL7902199 | 0.75 | PIK3CA (0.65) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL3791135 | 0.75 | PIK3CA (0.77) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL539256 | 0.74 | PIK3CA (0.78) | PIK3CAPIK3R1MTORPIK3CDJAK2 | |
| SCHEMBL2377374 | 0.74 | PIK3CA (0.68) | PIK3CAPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114494-A1 | 8-SUBSTITUTED-2-MORPHOLINO PURINES FOR USE AS PI3K AND/OR MTOR INHIBITORS IN THE TREATMENT OF PROLIFERATIVE DISORDERS | S*BIO PTE LTD (SG) | 2010-10-07 | — | — | WO | disclosed |