Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4115321 | 0.94 | ALDH1A1 (0.46) | ALDH1A1HPGDKMT2AMAPTKDM4E | |
| SCHEMBL1854752 | 0.86 | USP30 (0.47) | ALDH1A1HPGDKMT2AMAPTKDM4E | |
| SCHEMBL1851649 | 0.86 | USP30 (0.47) | ALDH1A1HPGDKMT2AMAPTKDM4E | |
| SCHEMBL4273196 | 0.85 | KMT2A (0.44) | ALDH1A1HPGDKMT2AMAPTKDM4E | |
| SCHEMBL4105160 | 0.85 | KMT2A (0.44) | ALDH1A1HPGDKMT2AMAPTKDM4E | |
| SCHEMBL1852384 | 0.84 | KMT2A (0.43) | ALDH1A1HPGDKMT2AMAPTKDM4E | |
| SCHEMBL4280778 | 0.83 | KMT2A (0.45) | ALDH1A1HPGDKMT2AMAPTKDM4E | |
| SCHEMBL4119304 | 0.83 | KMT2A (0.46) | ALDH1A1HPGDKMT2AMAPTKDM4E | |
| SCHEMBL1852526 | 0.82 | CYP3A4 (0.48) | ALDH1A1HPGDKMT2AMAPTKDM4E | |
| SCHEMBL1850141 | 0.80 | USP30 (0.53) | ALDH1A1KMT2AMAPTKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247559-A1 | Benzofuropyrimidinones | EXELIXIS, INC. (US) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247559-A1 | Benzofuropyrimidinones | F12, BRI3BP, BRD1 | ALDH1A1 315/4885HPGD 2284/4885KMT2A 2152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.