Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4128852 | 1.00 | EGFR (0.38) | EGFRCYP2C9SMN1; SMN2MAPTGAA | |
| Bromide SCHEMBL4134863 | 0.76 | MAPT (0.49) | SMN1; SMN2MAPTGAAMEN1KMT2A | |
| Bromide SCHEMBL4134861 | 0.76 | MAPT (0.49) | SMN1; SMN2MAPTGAAMEN1KMT2A | |
| Bromide SCHEMBL18523399 | 0.74 | TRPA1 (0.35) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| Bromide SCHEMBL4139679 | 0.72 | KMT2A (0.49) | SMN1; SMN2MEN1KMT2ALMNA | |
| Bromide SCHEMBL4139683 | 0.72 | KMT2A (0.49) | SMN1; SMN2MEN1KMT2ALMNA | |
| Bromide SCHEMBL4137969 | 0.71 | POLB (0.41) | CYP2C9GAAMEN1KMT2AALDH1A1 | |
| Bromide SCHEMBL4137968 | 0.71 | POLB (0.41) | CYP2C9GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL11119867 | 0.69 | EGFR (0.50) | EGFRCYP2C9SMN1; SMN2MAPTGAA | |
| SCHEMBL20857410 | 0.69 | TRPA1 (0.34) | ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163740-A1 | LIGANDS FOR METALS AS CATALYSTS FOR CARBON-CARBON BOND FORMATION | NATIONAL SUN YAT-SEN UNIVERSITY | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163740-A1 | LIGANDS FOR METALS AS CATALYSTS FOR CARBON-CARBON BOND FORMATION | NCOR2, OXGR1, NCOR1 | EGFR 1135/4885CYP2C9 471/4885SMN1; SMN2 3781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.