Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAN1B1 | Q9UKM7 | 7/20 | 0.59 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.49 |
| ▸ | GBA1 | P04062 | 8/20 | 0.46 |
| ▸ | GLB1 | P16278 | 1/20 | 0.46 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.46 |
| ▸ | MAN2A1 | Q16706 | 5/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | MAN2B1 | O00754 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617559 | 0.71 | MC4R (0.50) | MAN1B1FUCA1GBA1MC4RFYN | |
| SCHEMBL19881542 | 0.71 | MC4R (0.50) | MAN1B1FUCA1GBA1MC4RFYN | |
| SCHEMBL21578196 | 0.70 | MAN1B1 (0.64) | MAN1B1GBA1GLB1GBA2MAN2A1 | |
| SCHEMBL21578194 | 0.70 | MAN1B1 (0.64) | MAN1B1GBA1GLB1GBA2MAN2A1 | |
| SCHEMBL20470481 | 0.70 | MAN1B1 (0.64) | MAN1B1GBA1GLB1GBA2MAN2A1 | |
| SCHEMBL21578193 | 0.70 | MAN1B1 (0.64) | MAN1B1GBA1GLB1GBA2MAN2A1 | |
| SCHEMBL8322192 | 0.69 | FUCA1 (0.56) | FUCA1FYN | |
| SCHEMBL8322195 | 0.69 | FUCA1 (0.56) | FUCA1FYN | |
| SCHEMBL28716809 | 0.69 | GRIN2B (0.55) | FUCA1FYN | |
| SCHEMBL9369608 | 0.68 | FUCA1 (0.47) | MAN1B1FUCA1GBA1MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009118712-A2 | NOVEL DIHYDROXYPYRROLIDINE DERIVATIVES AS ANTI-CANCER AGENTS | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2009-10-01 | — | — | WO | disclosed |
| WO-2009072062-A2 | NOVEL DERIVATIVES OF DIHYDROXYPYRROLIDINE AS ANTI-CANCER COMPOUNDS | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2009-06-11 | — | — | WO | disclosed |
| EP-2067771-A1 | Derivatives of Dihydroxypyrrolidine as Anti-Cancer Compounds | EPFL Ecole Polytechnique Fédérale de Lausanne (CH) | 2009-06-10 | — | — | EP | disclosed |