Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 19/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1880234 | 0.96 | SSTR5 (0.67) | SSTR5HRH1KDM4EMEN1ALDH1A1 | |
| SCHEMBL1880914 | 0.91 | SSTR5 (0.64) | SSTR5KCNH2HRH1KDM4EMEN1 | |
| SCHEMBL1878438 | 0.87 | KDM4E (0.61) | SSTR5KCNH2HRH1KDM4EMEN1 | |
| SCHEMBL4130369 | 0.83 | SSTR5 (0.58) | SSTR5KCNH2 | |
| SCHEMBL4125485 | 0.82 | SSTR5 (0.65) | SSTR5KCNH2HRH1HTR2B | |
| SCHEMBL1876792 | 0.82 | SSTR5 (0.65) | SSTR5HRH1KDM4EMEN1ALDH1A1 | |
| SCHEMBL1881042 | 0.82 | SSTR5 (0.52) | SSTR5HRH1KDM4EMEN1ALDH1A1 | |
| SCHEMBL1880457 | 0.82 | KDM4E (0.54) | SSTR5HRH1KDM4EMEN1ALDH1A1 | |
| SCHEMBL1876062 | 0.82 | SSTR5 (0.64) | SSTR5HRH1KDM4EMEN1ALDH1A1 | |
| SCHEMBL1879016 | 0.81 | SSTR5 (0.65) | SSTR5HRH1KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066658-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-06-10 | — | — | EP | claimed |
| WO-2008031735-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-20 | — | — | WO | claimed |
| EP-2066658-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008031735-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-20 | — | — | WO | disclosed |