Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4141749 | 0.96 | MLNR (0.37) | ALDH1A1KDM4EHTR1DMLNRDRD2 | |
| SCHEMBL4139662 | 0.89 | PNMT (0.35) | ALDH1A1KDM4EMLNRDRD2DRD3 | |
| SCHEMBL4141084 | 0.89 | JAK2 (0.42) | ALDH1A1KDM4EDRD2DRD3PNMT | |
| SCHEMBL4139871 | 0.88 | USP30 (0.43) | ALDH1A1KDM4EHTR1DDRD3CYP2D6 | |
| SCHEMBL4128738 | 0.87 | USP30 (0.36) | ALDH1A1KDM4EDRD2DRD3 | |
| SCHEMBL4140906 | 0.87 | USP30 (0.43) | ALDH1A1KDM4EHTR1DDRD3CYP2D6 | |
| SCHEMBL4142661 | 0.87 | USP30 (0.43) | ALDH1A1KDM4EHTR1DDRD3CYP2D6 | |
| SCHEMBL4140902 | 0.87 | USP30 (0.43) | ALDH1A1KDM4EHTR1DDRD3CYP2D6 | |
| SCHEMBL4136797 | 0.87 | TP53 (0.40) | ALDH1A1KDM4EMLNRDRD2DRD3 | |
| SCHEMBL4136716 | 0.85 | HDAC4 (0.38) | ALDH1A1KDM4EDRD2DRD3PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163482-A1 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | MCHARDY STANTON FURST | 2009-06-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163482-A1 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | HRH3, HRH4, HRH1 | ALDH1A1 1667/4885KDM4E 4508/4885HTR1D 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.