Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.41 |
| ▸ | MTOR | P42345 | 5/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4122923 | 0.83 | PIK3CA (0.57) | PIK3CAMTORPIK3R1PIK3CG | |
| SCHEMBL3450472 | 0.77 | KDM4E (0.54) | TDP1KDM4ELMNAL3MBTL1HSD17B10 | |
| SCHEMBL3991612 | 0.77 | MTOR (0.46) | TDP1KDM4ELMNAL3MBTL1HSD17B10 | |
| SCHEMBL3452085 | 0.77 | NPSR1 (0.65) | TDP1KDM4ELMNAL3MBTL1HSD17B10 | |
| SCHEMBL3998571 | 0.76 | ALDH3A1 (0.53) | TDP1KDM4ELMNAL3MBTL1HSD17B10 | |
| SCHEMBL3991686 | 0.76 | TDP1 (0.51) | TDP1KDM4ELMNAL3MBTL1HSD17B10 | |
| SCHEMBL13588461 | 0.74 | MOK (0.60) | KDM4EPIK3CAMTORPIK3CGHPGD | |
| SCHEMBL3991683 | 0.74 | TDP1 (0.48) | TDP1KDM4ELMNAL3MBTL1HSD17B10 | |
| SCHEMBL2812564 | 0.73 | PIK3CA (0.64) | LMNAHSD17B10POLBHTTGPR55 | |
| SCHEMBL4927627 | 0.72 | TDP1 (0.48) | TDP1KDM4ELMNAL3MBTL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | disclosed |