Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.37 |
| ▸ | RAF1 | P04049 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 8/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13772990 | 0.87 | PTGS2 (0.42) | PTGS2MAPK14RAF1EGFRADORA3 | |
| SCHEMBL13772925 | 0.84 | BRAF (0.56) | RAF1BRAFMAPK3MAPK1BMPR1B | |
| SCHEMBL4138293 | 0.84 | BRAF (0.56) | RAF1BRAFMAPK3MAPK1BMPR1B | |
| SCHEMBL4127787 | 0.82 | BRAF (0.44) | PTGS2RAF1BRAFMAPK3MAPK1 | |
| SCHEMBL8836681 | 0.74 | PTGS2 (0.70) | PTGS2MAPK14RAF1EGFRADORA3 | |
| SCHEMBL8836442 | 0.74 | PTGS2 (0.70) | PTGS2MAPK14RAF1EGFRADORA3 | |
| SCHEMBL15639663 | 0.73 | CYP1A2 (0.57) | CYP1A2CYP11B1CYP11B2PTGS2GRM1 | |
| SCHEMBL8836701 | 0.71 | PTGS2 (0.53) | PTGS2MAPK14RAF1EGFRADORA3 | |
| SCHEMBL4138287 | 0.70 | BRAF (0.69) | MAPK14RAF1BRAFMAPK3MAPK1 | |
| SCHEMBL8836452 | 0.69 | PTGS2 (0.62) | PTGS2MAPK14RAF1EGFRADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090176809-A1 | RAF INHIBITOR COMPOUNDS AND METHODS | LAIRD ELLEN | 2009-07-09 | — | — | US | disclosed |
| US-7491829-B2 | RAF inhibitor compounds and methods | ARRAY BIOPHARMA INC. (US) | 2009-02-17 | — | — | US | disclosed |
| US-20060189627-A1 | RAF inhibitor compounds and methods | ARRAY BIOPHARMA INC. | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189627-A1 | RAF inhibitor compounds and methods | BRAF, RAF1, ARAF | CYP1A2 3511/4885CYP11B1 1525/4885CYP11B2 2113/4885 |
| US-20090176809-A1 | RAF INHIBITOR COMPOUNDS AND METHODS | BRAF, RAF1, ARAF | CYP1A2 3511/4885CYP11B1 1525/4885CYP11B2 2113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.