Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR2A | P27037 | 1/20 | 0.74 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.74 |
| ▸ | NAMPT | P43490 | 11/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL411369 | 0.85 | ACVR2A (1.00) | ACVR2ATGFBR2NAMPTL3MBTL1KDM4E | |
| SCHEMBL14490341 | 0.81 | ACVR2A (0.91) | ACVR2ATGFBR2NAMPTL3MBTL1KDM4E | |
| SCHEMBL21932072 | 0.75 | ACVR2A (0.80) | ACVR2ATGFBR2NAMPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL413843 | 0.75 | ACVR2A (0.78) | ACVR2ATGFBR2NAMPTKMT2A | |
| SCHEMBL3424283 | 0.73 | ACVR2A (0.64) | ACVR2ATGFBR2NAMPTL3MBTL1KDM4E | |
| SCHEMBL447681 | 0.73 | ACVR2A (0.78) | ACVR2ATGFBR2NAMPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL413784 | 0.72 | ACVR2A (0.75) | ACVR2ATGFBR2NAMPTGAAALDH1A1 | |
| SCHEMBL411189 | 0.72 | ACVR2A (0.79) | ACVR2ATGFBR2NAMPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL414392 | 0.71 | ACVR2A (0.76) | ACVR2ATGFBR2NAMPTL3MBTL1KDM4E | |
| SCHEMBL411736 | 0.71 | ACVR2A (0.72) | ACVR2ATGFBR2NAMPTL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140120621-A1 | TGF-BETA RECEPTOR INHIBITORS TO ENHANCE DIRECT REPROGRAMMING | THE GENERAL HOSPITAL CORPORATION (US) | 2014-05-01 | — | — | US | disclosed |
| US-8603818-B1 | TGF-beta receptor inhibitors to enhance direct reprogramming | THE GENERAL HOSPITAL CORPORATION (US) | 2013-12-10 | — | — | US | disclosed |
| US-8298825-B1 | TGF-beta receptor inhibitors to enhance direct reprogramming | THE GENERAL HOSPITAL CORPORATION (US) | 2012-10-30 | — | — | US | disclosed |
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |