Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ARG2 | P78540 | 2/20 | 0.31 |
| ▸ | ARG1 | P05089 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CETP | P11597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22576437 | 0.77 | CYP2C19 (0.38) | CYP2C19CYP1A2LMNAARG1ALDH1A1 | |
| SCHEMBL13464472 | 0.77 | CYP1A2 (0.51) | CYP2C19CYP1A2ARG1ALDH1A1KDM4E | |
| SCHEMBL11412763 | 0.76 | CYP2C19 (0.42) | CYP2C19CYP1A2LMNAALDH1A1KDM4E | |
| SCHEMBL18940910 | 0.74 | FFAR3 (0.41) | CYP2C19CYP1A2POLBLMNAARG2 | |
| SCHEMBL8021928 | 0.73 | CYP2C19 (0.35) | CYP2C19CYP1A2ALDH1A1 | |
| SCHEMBL1812100 | 0.71 | CYP2C19 (0.56) | CYP2C19CYP1A2LMNAMMEALDH1A1 | |
| SCHEMBL1055977 | 0.71 | — | — | |
| SCHEMBL13464557 | 0.70 | CYP1A2 (0.43) | CYP2C19CYP1A2ALDH1A1 | |
| SCHEMBL30186714 | 0.69 | CYP2C19 (0.60) | CYP2C19CYP1A2LMNAMMEALDH1A1 | |
| SCHEMBL9640977 | 0.69 | CYP2C19 (0.60) | CYP2C19CYP1A2LMNAMMEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| EP-1939205-A1 | TRICYCLIC COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2008-07-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | FDFT1, COASY, HMGCR | CYP2C19 1331/4885CYP1A2 352/4885POLB 2945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.